Table 2. X-inactivation ratios in... | American Society of Hematology

Table 2.

X-inactivation ratios in informative donor/recipient pairs

ID	Donor	Recipient
ID	Donor	Engraftment^*	2 mo	6 mo	12 mo
1	2.17	2.69	3.36	—	—
2	0.75	0.67	0.62	0.75	0.85
4	0.75	0.79	1.12	0.91	0.83
5	0.44	0.32	—	0.43	0.53
6	0.27	0.19	—	0.21	0.18
8	0.73	0.72	0.69	0.62	0.62
9	0.59	0.47	0.52	0.55	0.53
11	2.46	2.72	—	—	2.42
14	4.62	11.93	5.12	6.38	10.42
15	1.77	2.13	1.71	1.70	1.91
19	0.29	0.30	—	0.32	0.28

ID	Donor	Recipient
ID	Donor	Engraftment^*	2 mo	6 mo	12 mo
1	2.17	2.69	3.36	—	—
2	0.75	0.67	0.62	0.75	0.85
4	0.75	0.79	1.12	0.91	0.83
5	0.44	0.32	—	0.43	0.53
6	0.27	0.19	—	0.21	0.18
8	0.73	0.72	0.69	0.62	0.62
9	0.59	0.47	0.52	0.55	0.53
11	2.46	2.72	—	—	2.42
14	4.62	11.93	5.12	6.38	10.42
15	1.77	2.13	1.71	1.70	1.91
19	0.29	0.30	—	0.32	0.28

Excessive skewing, corresponding to more than 75% expression of one allele, is defined by ratios less than 0.33 or more than 3. Ratios in D14 (4.62) and in R14 (11.93) at the time of engraftment correspond to expression of the dominant allele in approximately 83% and 92% of cells, respectively. Note that D6, D14, and D19 have skewed ratios and that R1 and R5 acquire skewed ratios at 2 months after HSCT and transiently at the time of engraftment, respectively. Overall, consistency in X-inactivation ratios within donor/recipient pairs is demonstrated.

Sample taken within 2 weeks of attainment of absolute neutrophil count of 0.5 × 10⁹/L; most recipients were red cell and platelet transfusion–dependent at this time.

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