Clinical and histologic features of the 46 DLBCLs
| Subject no. . | Case . | Age/Sex . | Rx . | Study . | Specimen . | Morphology . | Stage . | IPI . | Response . | TTP, mo . | OS, mo . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 980 | 32/M | UT | ID | Cervical node | CB | — | — | — | — | — | LF |
| 2 | 1942 | 29/M | UT | ID | Colonic mass | CB | II XEA | LR | CR | 47.0 | 47.0 | NED |
| 3 | 1965 | 58/F | UT | ID | Jugular node | CB | II A | LR | CR | 40.0 | 40.0 | NED |
| 4 | 1997 | 44/M | UT | ID | Axillary node | CB | III B | HR | CR | 9.6 | 16.3 | DOD |
| 5 | 2045 | 68/F | UT | ID | Tonsil | CB | II EA | LR | CR | 39.4 | 39.4 | NED |
| 6 | 2180 | 33/M | UT | ID | Stomach | CB | I EA | LR | CR | 15.4 | 15.4 | NED |
| 7 | 2202 | 82/M | UT | ID | Retroperitoneal mass | CB | III A | LR | NR* | 4.8 | 4.8 | DOD |
| 8 | 2270 | 59/M | UT | PRD | Inguinal node | CB | I A | LR | NR | 2.9 | 28.8 | NED |
| 9 | 2326 | 50/M | UT | ID | Neck node | CB | III A | LR | CR | 12.9 | 12.9 | NED |
| 10 | 2358 | 74/F | UT | ID | Neck mass | TCR/HR | IV A | HR | — | — | — | LF |
| 11 | 2417 | 21/F | UT | ID | Cervical node | PL | IV A | LR | CR | 6.8 | 8.1 | AWD |
| 12 | 2438 | 57/F | UT | ID | Inguinal node | CB | IV B | HR | CR | 11.7 | 11.7 | NED |
| 13 | 2447 | 65/F | UT | ID | Right thigh | PB | II EX | HR | CR | 9.4 | 9.4 | NED |
| 14 | 2451 | 71/M | UT | ID | Inguinal node | CB | IV A | HR | CR | 10.3 | 10.3 | NED |
| 15 | 2453 | 64/F | UT | ID | Axillary node | TCR/HR | IV A | HR | POD | 2.7 | 5.6 | DOD |
| 16 | 2511 | 55/M | UT | ID | Axillary node | TCR/HR | III A | LR | CR | 6.8 | 6.8 | NED |
| 17 | 2526 | 77/F | UT | ID | Cervical node | PB | I A | LR | CR | 5.1 | 5.1 | NED |
| 18 | 2536 | 72/F | UT | ID | Axillary node | CB | IV A | HR | CR | 4.8 | 4.8 | AWD |
| 19 | 2545 | 83/M | UT | ID | Inguinal node | TCR/HR | III A | LR | No Rx | 5.3 | 5.3 | AWD |
| 20 | 2625 | 61/F | UT | ID | Neck mass | CB | I A | LR | CR | 5.1 | 5.1 | NED |
| 21 | 2627 | 82/F | UT | ID | Spleen | CB | I A | HR | CR* | 4.3 | 4.3 | NED |
| 22 | 2629 | 59/F | UT | ID | Hepatic artery node | CB | II A | LR | CR | 5.6 | 5.6 | AWD |
| 23 | 2609 | 53/M | UT | ID | Bone marrow | IM | IV B | LR | POD | 4.6 | 5.9 | DOD |
| 24† | 2612 | 52/F | UT | ID | Ascitic fluid | — | IV A | LR | CR | 18.7 | 18.7 | NED |
| 25 | 2433 | 73/F | UT | ID | Jugular node | TCR/HR | III A | HR | — | — | — | LF |
| 26 | 2411 | 60/M | UT | ID | Neck mass | IM | IV A | LR | CR | 8.5 | 8.5 | NED |
| 27 | 2055 | 71/F | UT | ID | Epiglottis | PB | I EA | LR | CR | 25.7 | 25.7 | DOD |
| 28 | 2308 | 77/F | UT | ID | Pelvic node | CB | III BE | HR | CR | 17.8 | 17.8 | NED |
| 29 | 2549 | 85/F | UT | ID | Tonsil | CB | IV A | LR | CR | 5.8 | 5.8 | NED |
| 30 | 2216 | 35/F | T | 2nd RP | Omentum | PL | II XA | LR | NR | 4.4 | 10.2 | DOD |
| 31‡ | 2293 | 37/F | T | 2nd RP | Level II neck node | CB | II XA | LR | CR | 20.6 | 58.8 | AWD |
| 32 | 2616 | 43/M | T | PRD | Bone marrow | CB | IV A | LR | POD | 4.6 | 10.1 | DOD |
| 33‡ | 2473 | 37/M | T | PRD | Supraclavicular node | CB | II XEEB | HR | POD | 6.7 | 14.7 | NED |
| 34 | 2631 | 57/M | T | 2nd RP | Antecubital fossa | CB | IV A | HR | CR | 11 | 24.2 | AWD |
| 35 | 2369 | 39/M | T | PRD | Pancreas | IM | IV XB | HR | NR | 4.7 | 10.5 | DOD |
| 36 | 2552 | 46/M | T | 2nd RP | Cervical node | CB | III A | LR | CR | 11.7 | 22.8 | AWD |
| 37 | 2498 | 57/F | T | 1st RP | Axillary node | IM | I A | LR | CR | 6 | 12.3 | NED |
| 38 | 2005 | 42/F | T | 1st RP | Axillary node | PL | III ARE | LR | CR | 8.7 | 37.8 | DOD |
| 39 | 1778 | 37/F | T | 2nd RP | Jugular node | CB | IV A | HR | CR | 15.7 | 30.1 | DOD |
| 40 | 2020 | 63/M | T | 1st RP | Spleen | CB | IV A | HR | CR | 16.5 | 36.8 | DOD |
| 41 | 1983 | 66/F | T | 1st RP | Scalene node | CB | I A | LR | CR | 8.6 | 33.0 | DOD |
| 42‡ | 1800 | 28/M | T | PRD | Supraclavicular node | CB | II A | LR | PR | 5.6 | 45.7 | NED |
| 43 | 2006 | 23/M | T | 1st RP | Axillary node | PB | III A | LR | CR | 7.2 | 12.1 | DOD |
| 44 | 2287 | 48/M | T | 2nd RP | Scalene node | CB | IV A | HR | PR | 9.1 | 16.7 | DOD |
| 45 | 1686 | 61/F | T | 1st RP | Cervical node | PB | II XA | LR | CR | 243.4 | 319.2 | NED |
| 46 | 2635 | 82/F | T | 2nd RP | Axillary node | CB | II A | HR | CR | 155.9 | 226.2 | DOD |
| Subject no. . | Case . | Age/Sex . | Rx . | Study . | Specimen . | Morphology . | Stage . | IPI . | Response . | TTP, mo . | OS, mo . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 980 | 32/M | UT | ID | Cervical node | CB | — | — | — | — | — | LF |
| 2 | 1942 | 29/M | UT | ID | Colonic mass | CB | II XEA | LR | CR | 47.0 | 47.0 | NED |
| 3 | 1965 | 58/F | UT | ID | Jugular node | CB | II A | LR | CR | 40.0 | 40.0 | NED |
| 4 | 1997 | 44/M | UT | ID | Axillary node | CB | III B | HR | CR | 9.6 | 16.3 | DOD |
| 5 | 2045 | 68/F | UT | ID | Tonsil | CB | II EA | LR | CR | 39.4 | 39.4 | NED |
| 6 | 2180 | 33/M | UT | ID | Stomach | CB | I EA | LR | CR | 15.4 | 15.4 | NED |
| 7 | 2202 | 82/M | UT | ID | Retroperitoneal mass | CB | III A | LR | NR* | 4.8 | 4.8 | DOD |
| 8 | 2270 | 59/M | UT | PRD | Inguinal node | CB | I A | LR | NR | 2.9 | 28.8 | NED |
| 9 | 2326 | 50/M | UT | ID | Neck node | CB | III A | LR | CR | 12.9 | 12.9 | NED |
| 10 | 2358 | 74/F | UT | ID | Neck mass | TCR/HR | IV A | HR | — | — | — | LF |
| 11 | 2417 | 21/F | UT | ID | Cervical node | PL | IV A | LR | CR | 6.8 | 8.1 | AWD |
| 12 | 2438 | 57/F | UT | ID | Inguinal node | CB | IV B | HR | CR | 11.7 | 11.7 | NED |
| 13 | 2447 | 65/F | UT | ID | Right thigh | PB | II EX | HR | CR | 9.4 | 9.4 | NED |
| 14 | 2451 | 71/M | UT | ID | Inguinal node | CB | IV A | HR | CR | 10.3 | 10.3 | NED |
| 15 | 2453 | 64/F | UT | ID | Axillary node | TCR/HR | IV A | HR | POD | 2.7 | 5.6 | DOD |
| 16 | 2511 | 55/M | UT | ID | Axillary node | TCR/HR | III A | LR | CR | 6.8 | 6.8 | NED |
| 17 | 2526 | 77/F | UT | ID | Cervical node | PB | I A | LR | CR | 5.1 | 5.1 | NED |
| 18 | 2536 | 72/F | UT | ID | Axillary node | CB | IV A | HR | CR | 4.8 | 4.8 | AWD |
| 19 | 2545 | 83/M | UT | ID | Inguinal node | TCR/HR | III A | LR | No Rx | 5.3 | 5.3 | AWD |
| 20 | 2625 | 61/F | UT | ID | Neck mass | CB | I A | LR | CR | 5.1 | 5.1 | NED |
| 21 | 2627 | 82/F | UT | ID | Spleen | CB | I A | HR | CR* | 4.3 | 4.3 | NED |
| 22 | 2629 | 59/F | UT | ID | Hepatic artery node | CB | II A | LR | CR | 5.6 | 5.6 | AWD |
| 23 | 2609 | 53/M | UT | ID | Bone marrow | IM | IV B | LR | POD | 4.6 | 5.9 | DOD |
| 24† | 2612 | 52/F | UT | ID | Ascitic fluid | — | IV A | LR | CR | 18.7 | 18.7 | NED |
| 25 | 2433 | 73/F | UT | ID | Jugular node | TCR/HR | III A | HR | — | — | — | LF |
| 26 | 2411 | 60/M | UT | ID | Neck mass | IM | IV A | LR | CR | 8.5 | 8.5 | NED |
| 27 | 2055 | 71/F | UT | ID | Epiglottis | PB | I EA | LR | CR | 25.7 | 25.7 | DOD |
| 28 | 2308 | 77/F | UT | ID | Pelvic node | CB | III BE | HR | CR | 17.8 | 17.8 | NED |
| 29 | 2549 | 85/F | UT | ID | Tonsil | CB | IV A | LR | CR | 5.8 | 5.8 | NED |
| 30 | 2216 | 35/F | T | 2nd RP | Omentum | PL | II XA | LR | NR | 4.4 | 10.2 | DOD |
| 31‡ | 2293 | 37/F | T | 2nd RP | Level II neck node | CB | II XA | LR | CR | 20.6 | 58.8 | AWD |
| 32 | 2616 | 43/M | T | PRD | Bone marrow | CB | IV A | LR | POD | 4.6 | 10.1 | DOD |
| 33‡ | 2473 | 37/M | T | PRD | Supraclavicular node | CB | II XEEB | HR | POD | 6.7 | 14.7 | NED |
| 34 | 2631 | 57/M | T | 2nd RP | Antecubital fossa | CB | IV A | HR | CR | 11 | 24.2 | AWD |
| 35 | 2369 | 39/M | T | PRD | Pancreas | IM | IV XB | HR | NR | 4.7 | 10.5 | DOD |
| 36 | 2552 | 46/M | T | 2nd RP | Cervical node | CB | III A | LR | CR | 11.7 | 22.8 | AWD |
| 37 | 2498 | 57/F | T | 1st RP | Axillary node | IM | I A | LR | CR | 6 | 12.3 | NED |
| 38 | 2005 | 42/F | T | 1st RP | Axillary node | PL | III ARE | LR | CR | 8.7 | 37.8 | DOD |
| 39 | 1778 | 37/F | T | 2nd RP | Jugular node | CB | IV A | HR | CR | 15.7 | 30.1 | DOD |
| 40 | 2020 | 63/M | T | 1st RP | Spleen | CB | IV A | HR | CR | 16.5 | 36.8 | DOD |
| 41 | 1983 | 66/F | T | 1st RP | Scalene node | CB | I A | LR | CR | 8.6 | 33.0 | DOD |
| 42‡ | 1800 | 28/M | T | PRD | Supraclavicular node | CB | II A | LR | PR | 5.6 | 45.7 | NED |
| 43 | 2006 | 23/M | T | 1st RP | Axillary node | PB | III A | LR | CR | 7.2 | 12.1 | DOD |
| 44 | 2287 | 48/M | T | 2nd RP | Scalene node | CB | IV A | HR | PR | 9.1 | 16.7 | DOD |
| 45 | 1686 | 61/F | T | 1st RP | Cervical node | PB | II XA | LR | CR | 243.4 | 319.2 | NED |
| 46 | 2635 | 82/F | T | 2nd RP | Axillary node | CB | II A | HR | CR | 155.9 | 226.2 | DOD |
Rx indicates treatment; IPI, international prognostic index; TTP, time to progression; OS, overall survival; UT, untreated; T, treated; ID, initial diagnosis; PRD, primary refractory disease; RP, relapse; CB, centroblastic; TCR/HR, T-cell-rich/histiocyte-rich; PL, pleomorphic; PB, plasmablastic; IM, immunoblastic; HR, high and high-intermediate risk; LR, low and low-intermediate risk; CR, complete remission; NR, no response; POD, progressive disease; PR, partial remission; DOD, died of disease; NED, no evidence of disease; LF, lost to follow-up; AWD, alive with disease.
Did not receive anthracycline-containing combination chemotherapy as part of their initial treatment.
Primary effusion lymphoma.
Mediastinal large B-cell lymphoma.