Locations of brain lesions at baseline for HbSS children with silent infarcts compared to those with a history of stroke
| Location . | Silent infarct (n = 58) . | Prior stroke (n = 18) . | Odds ratio4-150 . |
|---|---|---|---|
| Frontal lobe | 81.0% | 94.4% | 1.27 |
| Cortex | 17.0 | 82.4 | 0.054-151 |
| White matter | 100 | 100 | Indet |
| Parietal lobe | 44.8 | 77.8 | 4.56 |
| Cortex | 34.6 | 85.7 | 0.09‡ |
| White matter | 100 | 100 | Indet |
| Temporal lobe | 8.6 | 33.3 | 1.34 |
| Cortex | 20.0 | 50.0 | 0.25 |
| White matter | 80.0 | 83.3 | 0.80 |
| Occipital lobe | 1.7 | 11.1 | 1.26 |
| Cortex | 100 | 100 | Indet |
| White matter | 100 | 50.0 | Inf |
| Basal ganglia and thalamus | 15.5 | 66.7 | 0.254-153 |
| Capsular/corona | 3.4 | 5.6 | Inf |
| Cerebellum | 5.2 | 0.0 | Inf |
| Cortex | 20.7 | 77.8 | 0.25 |
| White matter | 89.7 | 94.4 | 2.18 |
| Location . | Silent infarct (n = 58) . | Prior stroke (n = 18) . | Odds ratio4-150 . |
|---|---|---|---|
| Frontal lobe | 81.0% | 94.4% | 1.27 |
| Cortex | 17.0 | 82.4 | 0.054-151 |
| White matter | 100 | 100 | Indet |
| Parietal lobe | 44.8 | 77.8 | 4.56 |
| Cortex | 34.6 | 85.7 | 0.09‡ |
| White matter | 100 | 100 | Indet |
| Temporal lobe | 8.6 | 33.3 | 1.34 |
| Cortex | 20.0 | 50.0 | 0.25 |
| White matter | 80.0 | 83.3 | 0.80 |
| Occipital lobe | 1.7 | 11.1 | 1.26 |
| Cortex | 100 | 100 | Indet |
| White matter | 100 | 50.0 | Inf |
| Basal ganglia and thalamus | 15.5 | 66.7 | 0.254-153 |
| Capsular/corona | 3.4 | 5.6 | Inf |
| Cerebellum | 5.2 | 0.0 | Inf |
| Cortex | 20.7 | 77.8 | 0.25 |
| White matter | 89.7 | 94.4 | 2.18 |
Many children had more than one lesion. Many lesions involved more than one area. For each lobe, lesions are further characterized as involving the cortex or white matter.
Indet indicates the odds ratio is indeterminate because both odds are zero or infinity; Inf, infinite odds ratio.
Odds ratios are listed for the odds of a lesion in the specified location among children with silent infarcts relative to the odds of a lesion in that location among children with a history of stroke.
P < .001.
P < .01.
Indicates .05 < P < .10.