Normalized array hybridization signal intensities and relative levels of expression of rhesus macaque chemokine messenger RNAs in spleen
| Chemokine . | Disease state . | Ratios . | ||||
|---|---|---|---|---|---|---|
| AIDS . | Acute . | UI . | AIDS:UI . | AIDS:acute . | UI:AIDS . | |
| BLC/BCA-1/CXCL13 | 0.64 | 0.47 | 0.22 | 2.9* | 1.3 | 0.3 |
| MIG/CXCL9 | 0.50 | 0.30 | 0.15 | 3.3* | 1.7 | 0.3 |
| IP-10/CXCL10 | 0.38 | 0.34 | 0.32 | 1.2 | 1.1 | 0.8 |
| Midkine | 0.35 | 0.39 | 0.47 | 0.8 | 0.9 | 1.3 |
| 6Ckine/CCL21 | 0.32 | 0.33 | 0.44 | 0.7 | 1.0 | 1.3 |
| MIP-3β/CCL19 | 0.26 | 0.24 | 0.14 | 1.9 | 1.1 | 0.5 |
| ENA-78/CXCL5 | 0.25 | 0.22 | 0.16 | 1.6 | 1.2 | 0.6 |
| GRO-γ/CXCL3 | 0.21 | 0.25 | 0.50 | 0.4 | 0.9 | 2.3* |
| SDF-1/CXCL12 | 0.21 | 0.35 | 0.26 | 0.8 | 0.6 | 1.2 |
| LDGF | 0.20 | 0.17 | 0.41 | 0.5 | 1.2 | 2.0* |
| MIP-1β/CCL4 | 0.19 | 0.22 | 0.61 | 0.3 | 0.8 | 3.3* |
| GRO-β/CXCL2 | 0.18 | 0.21 | 0.54 | 0.3 | 0.8 | 3.0* |
| MIP-1α/CCL3 | 0.17 | 0.12 | 0.20 | 0.9 | 1.5 | 1.2 |
| RANTES/CCL5 | 0.17 | 0.30 | 0.25 | 0.7 | 0.6 | 1.5 |
| Lymphotactin/XCL1 | 0.14 | 0.16 | 0.38 | 0.4 | 0.9 | 2.6* |
| MPIF-1/CCL23 | 0.14 | 0.18 | 0.22 | 0.6 | 0.8 | 1.6 |
| DC-CK-1/PARC/CCL18 | 0.13 | 0.13 | 0.17 | 0.8 | 1.0 | 1.3 |
| GRO-α/CXCL1 | 0.13 | 0.19 | 0.50 | 0.3 | 0.7 | 3.9* |
| Eotaxin-2/CCL24 | 0.12 | 0.12 | 0.15 | 0.8 | 1.0 | 1.2 |
| MCP-1/CCL2 | 0.11 | 0.14 | 0.27 | 0.4 | 0.8 | 2.4* |
| HCC-4/CCL16 | 0.11 | 0.11 | 0.16 | 0.6 | 0.9 | 1.6 |
| Fractalkine/CX3CL1 | 0.10 | 0.17 | 0.18 | 0.6 | 0.6 | 1.7 |
| MCP-4/CCL13 | 0.10 | 0.10 | 0.11 | 0.9 | 1.0 | 1.1 |
| HCC-1/CCL14 | 0.10 | 0.10 | 0.16 | 0.6 | 1.0 | 1.7 |
| MCP-2/CCL8 | 0.09 | 0.14 | 0.13 | 0.7 | 0.6 | 1.5 |
| IL-8/CXCL8 | 0.09 | 0.04 | 0.12 | 0.8 | 2.1 | 1.3 |
| MCP-3/CCL7 | 0.08 | 0.10 | 0.12 | 0.7 | 0.8 | 1.4 |
| MIP-3α/CCL20 | 0.08 | 0.07 | 0.15 | 0.5 | 1.1 | 1.9 |
| I-309/CCL1 | 0.08 | 0.04 | 0.13 | 0.6 | 1.8 | 1.7 |
| MIP-1δ/CCL15 | 0.08 | 0.11 | 0.38 | 0.2 | 0.7 | 5.0* |
| TARC/CCL17 | 0.07 | 0.10 | 0.07 | 1.0 | 0.7 | 1.0 |
| Eotaxin/CCL11 | 0.07 | 0.08 | 0.14 | 0.5 | 0.9 | 2.1 |
| MDC/CCL22 | 0.04 | 0.10 | 0.16 | 0.3 | 0.4 | 3.8 |
| TECK/CCL25 | 0.03 | 0.08 | 0.15 | 0.2 | 0.3 | 5.5 |
| Chemokine . | Disease state . | Ratios . | ||||
|---|---|---|---|---|---|---|
| AIDS . | Acute . | UI . | AIDS:UI . | AIDS:acute . | UI:AIDS . | |
| BLC/BCA-1/CXCL13 | 0.64 | 0.47 | 0.22 | 2.9* | 1.3 | 0.3 |
| MIG/CXCL9 | 0.50 | 0.30 | 0.15 | 3.3* | 1.7 | 0.3 |
| IP-10/CXCL10 | 0.38 | 0.34 | 0.32 | 1.2 | 1.1 | 0.8 |
| Midkine | 0.35 | 0.39 | 0.47 | 0.8 | 0.9 | 1.3 |
| 6Ckine/CCL21 | 0.32 | 0.33 | 0.44 | 0.7 | 1.0 | 1.3 |
| MIP-3β/CCL19 | 0.26 | 0.24 | 0.14 | 1.9 | 1.1 | 0.5 |
| ENA-78/CXCL5 | 0.25 | 0.22 | 0.16 | 1.6 | 1.2 | 0.6 |
| GRO-γ/CXCL3 | 0.21 | 0.25 | 0.50 | 0.4 | 0.9 | 2.3* |
| SDF-1/CXCL12 | 0.21 | 0.35 | 0.26 | 0.8 | 0.6 | 1.2 |
| LDGF | 0.20 | 0.17 | 0.41 | 0.5 | 1.2 | 2.0* |
| MIP-1β/CCL4 | 0.19 | 0.22 | 0.61 | 0.3 | 0.8 | 3.3* |
| GRO-β/CXCL2 | 0.18 | 0.21 | 0.54 | 0.3 | 0.8 | 3.0* |
| MIP-1α/CCL3 | 0.17 | 0.12 | 0.20 | 0.9 | 1.5 | 1.2 |
| RANTES/CCL5 | 0.17 | 0.30 | 0.25 | 0.7 | 0.6 | 1.5 |
| Lymphotactin/XCL1 | 0.14 | 0.16 | 0.38 | 0.4 | 0.9 | 2.6* |
| MPIF-1/CCL23 | 0.14 | 0.18 | 0.22 | 0.6 | 0.8 | 1.6 |
| DC-CK-1/PARC/CCL18 | 0.13 | 0.13 | 0.17 | 0.8 | 1.0 | 1.3 |
| GRO-α/CXCL1 | 0.13 | 0.19 | 0.50 | 0.3 | 0.7 | 3.9* |
| Eotaxin-2/CCL24 | 0.12 | 0.12 | 0.15 | 0.8 | 1.0 | 1.2 |
| MCP-1/CCL2 | 0.11 | 0.14 | 0.27 | 0.4 | 0.8 | 2.4* |
| HCC-4/CCL16 | 0.11 | 0.11 | 0.16 | 0.6 | 0.9 | 1.6 |
| Fractalkine/CX3CL1 | 0.10 | 0.17 | 0.18 | 0.6 | 0.6 | 1.7 |
| MCP-4/CCL13 | 0.10 | 0.10 | 0.11 | 0.9 | 1.0 | 1.1 |
| HCC-1/CCL14 | 0.10 | 0.10 | 0.16 | 0.6 | 1.0 | 1.7 |
| MCP-2/CCL8 | 0.09 | 0.14 | 0.13 | 0.7 | 0.6 | 1.5 |
| IL-8/CXCL8 | 0.09 | 0.04 | 0.12 | 0.8 | 2.1 | 1.3 |
| MCP-3/CCL7 | 0.08 | 0.10 | 0.12 | 0.7 | 0.8 | 1.4 |
| MIP-3α/CCL20 | 0.08 | 0.07 | 0.15 | 0.5 | 1.1 | 1.9 |
| I-309/CCL1 | 0.08 | 0.04 | 0.13 | 0.6 | 1.8 | 1.7 |
| MIP-1δ/CCL15 | 0.08 | 0.11 | 0.38 | 0.2 | 0.7 | 5.0* |
| TARC/CCL17 | 0.07 | 0.10 | 0.07 | 1.0 | 0.7 | 1.0 |
| Eotaxin/CCL11 | 0.07 | 0.08 | 0.14 | 0.5 | 0.9 | 2.1 |
| MDC/CCL22 | 0.04 | 0.10 | 0.16 | 0.3 | 0.4 | 3.8 |
| TECK/CCL25 | 0.03 | 0.08 | 0.15 | 0.2 | 0.3 | 5.5 |
The values in the first 3 columns are normalized signal-intensity values obtained by DNA filter array hybridization. AIDS indicates acquired immunodeficiency syndrome; and UI, uninfected.
Ratios of normalized signal intensities ≥ 2.0 and that are derived by values of which one is ≥ 0.20. The mean ± 2 SD of the negative control hybridization targets on these filters ranged from 0.13 to 0.19, and we used a normalized signal-intensity value of 0.2 as a highly conservative cutoff value for what was considered to be at or above the level of sensitivity of the assay.