Comparison of efficiencies and net iron balance of IV and SC HBED versus those of IV and SC DFO in C apella primates
| Drug . | Route . | Dose (μmol/kg) . | Dose (mg/kg) . | n . | Efficiency (%) . | Induced Fe (μg/kg) . | Fe balance (μg/kg)* . |
|---|---|---|---|---|---|---|---|
| DFO | SC bolus | 75 | 50 | 4 | 5.0 ± 2.6 | 213 ± 112 | −60 ± 135 |
| DFO† | SC bolus | 150 | 100 | 6 | 5.1 ± 1.3 | 435 ± 115 | −278 ± 185 |
| DFO | 20-min IV inf | 75 | 50 | 5 | 5.6 ± 1.6 | 237 ± 67 | −22 ± 197 |
| DFO | 20-min IV inf | 150 | 100 | 5 | 3.9 ± 0.8 | 332 ± 66 | −168 ± 51 |
| HBED‡ | SC bolus | 75 | 32.4 | 4 | 14.2 ± 2.2 | 597 ± 91 | −524 ± 84 |
| HBED1-153 | SC bolus | 150 | 64.9 | 5 | 13.6 ± 4.5 | 1139 ± 383 | −899 ± 365 |
| HBED | IV bolus | 50 | 21.6 | 5 | 12.1 ± 2.5 | 338 ± 68 | −195 ± 114 |
| HBED | IV bolus | 75 | 32.4 | 4 | 11.5 ± 1.3 | 482 ± 54 | −407 ± 73 |
| HBED | 20 min IV inf | 150 | 64.9 | 4 | 7.7 ± 0.8 | 644 ± 65 | −408 ± 77 |
| HBED | 20 min IV inf | 225 | 97.3 | 5 | 6.3 ± 1.0 | 798 ± 126 | −570 ± 248 |
| Drug . | Route . | Dose (μmol/kg) . | Dose (mg/kg) . | n . | Efficiency (%) . | Induced Fe (μg/kg) . | Fe balance (μg/kg)* . |
|---|---|---|---|---|---|---|---|
| DFO | SC bolus | 75 | 50 | 4 | 5.0 ± 2.6 | 213 ± 112 | −60 ± 135 |
| DFO† | SC bolus | 150 | 100 | 6 | 5.1 ± 1.3 | 435 ± 115 | −278 ± 185 |
| DFO | 20-min IV inf | 75 | 50 | 5 | 5.6 ± 1.6 | 237 ± 67 | −22 ± 197 |
| DFO | 20-min IV inf | 150 | 100 | 5 | 3.9 ± 0.8 | 332 ± 66 | −168 ± 51 |
| HBED‡ | SC bolus | 75 | 32.4 | 4 | 14.2 ± 2.2 | 597 ± 91 | −524 ± 84 |
| HBED1-153 | SC bolus | 150 | 64.9 | 5 | 13.6 ± 4.5 | 1139 ± 383 | −899 ± 365 |
| HBED | IV bolus | 50 | 21.6 | 5 | 12.1 ± 2.5 | 338 ± 68 | −195 ± 114 |
| HBED | IV bolus | 75 | 32.4 | 4 | 11.5 ± 1.3 | 482 ± 54 | −407 ± 73 |
| HBED | 20 min IV inf | 150 | 64.9 | 4 | 7.7 ± 0.8 | 644 ± 65 | −408 ± 77 |
| HBED | 20 min IV inf | 225 | 97.3 | 5 | 6.3 ± 1.0 | 798 ± 126 | −570 ± 248 |
Net iron balance = dietary iron intake − (urinary iron + fecal iron). Animals in a negative iron balance are excreting more iron than they are absorbing. To maintain iron balance, 250 to 400 μg Fe/kg/day42 = 1750 to 2800 μg Fe/kg/week must be cleared.
Previously published.32
Derived from our previously published study33in which the monkeys were given 75 μmol/kg as an SC bolus in saline on days 0, 2, and 4; the day +1 to day +2 versus day −3 to day 0 iron balance figures are shown.
Previously published.33