Variables included in multivariable analysis for each end point
| End points . | Variables . |
|---|---|
| Neutrophil engraftment | BuCy, CD34 ≥ 3.0 × 106/kg, donor female to recipient male, female recipient, irradiation-based regimen, NC ≥ 2.4 × 108/kg |
| Secondary neutropenia | Advanced stage, BuCy, CD34 ≥ 3.0 × 106/kg, female recipient, NC ≥ 2.4 × 108/kg, gender match |
| Monocyte recovery | BuCy, CD34 ≥ 3.0 × 106/kg, female recipient, irradiation-based regimen, weight |
| Lymphocyte recovery | Acute leukemia, age, age of donor, CD34 ≥ 3.0 × 106/kg, chronic leukemia, female donor to a male recipient, NC ≥ 2.4 × 108/kg, positive CMV serology, weight |
| Hemoglobin recovery | CD34 ≥ 3.0 × 106/kg, chronic leukemia, NC ≥ 2.4 × 108/kg, gender match |
| Platelet engraftment | CD34 ≥ 3 × 106/kg, female recipient, advanced stage, irradiation-based regimen, malignancy, NC ≥ 2.4 × 108/kg |
| Invasive fungal infection | Acute leukemia, advanced stage, age, CD34 ≥ 3 × 106/kg, donor age, NC ≥ 2.4 × 108/kg, other malignancies |
| Transplantation-related mortality | ABO major incompatibility, advanced stage, age, CD34 ≥ 3 × 106/kg, donor age, donor sex, irradiation-based regimen, NC ≥ 2.4 × 108/kg, weight |
| Overall survival | ABO major incompatibility, advanced stage, age, BuCy, CD34 > 3 × 106/kg, positive CMV donor serology, donor age, female recipient, irradiation-based regimen, malignancy, NC ≥ 2.4 × 108/kg, other malignancies, weight |
| End points . | Variables . |
|---|---|
| Neutrophil engraftment | BuCy, CD34 ≥ 3.0 × 106/kg, donor female to recipient male, female recipient, irradiation-based regimen, NC ≥ 2.4 × 108/kg |
| Secondary neutropenia | Advanced stage, BuCy, CD34 ≥ 3.0 × 106/kg, female recipient, NC ≥ 2.4 × 108/kg, gender match |
| Monocyte recovery | BuCy, CD34 ≥ 3.0 × 106/kg, female recipient, irradiation-based regimen, weight |
| Lymphocyte recovery | Acute leukemia, age, age of donor, CD34 ≥ 3.0 × 106/kg, chronic leukemia, female donor to a male recipient, NC ≥ 2.4 × 108/kg, positive CMV serology, weight |
| Hemoglobin recovery | CD34 ≥ 3.0 × 106/kg, chronic leukemia, NC ≥ 2.4 × 108/kg, gender match |
| Platelet engraftment | CD34 ≥ 3 × 106/kg, female recipient, advanced stage, irradiation-based regimen, malignancy, NC ≥ 2.4 × 108/kg |
| Invasive fungal infection | Acute leukemia, advanced stage, age, CD34 ≥ 3 × 106/kg, donor age, NC ≥ 2.4 × 108/kg, other malignancies |
| Transplantation-related mortality | ABO major incompatibility, advanced stage, age, CD34 ≥ 3 × 106/kg, donor age, donor sex, irradiation-based regimen, NC ≥ 2.4 × 108/kg, weight |
| Overall survival | ABO major incompatibility, advanced stage, age, BuCy, CD34 > 3 × 106/kg, positive CMV donor serology, donor age, female recipient, irradiation-based regimen, malignancy, NC ≥ 2.4 × 108/kg, other malignancies, weight |
These variables were previously selected as having prognostic value at 10% level.
BuCy indicates busulfan associated to cyclophosphamide for the preparative regimen; NC, nucleated cells infused; CMV, cytomegalovirus.