ALL patients: outcome by arm
| . | E coli–asparaginase N = 334 (100%) . | Erwinia-asparaginase N = 319 (100%) . | Odds ratio (95% CI) (P)6-150 . |
|---|---|---|---|
| CR not reached after induction | 12 (3.6) | 21 (6.6) | 1.89 (0.87, 4.29) |
| (.107) | |||
| Remission failure | 4 (1.2) | 12 (3.8) | 3.23 (0.96, 13.84) |
| (.042) | |||
| CR reached | 330 (98.8) | 307 (96.2) | |
| Continuous CR | 242 [73] | 190 [62] | |
| Death in CR | 11 [3] | 7 [2] | |
| Relapses | 77 [23] | 110 [36] | |
| Bone marrow | 45 [14] | 64 [21] | |
| CNS (isolated) | 12 [4] | 18 [6] | |
| CNS (combined) | 13 [4] | 15 [5] | |
| Other isolated | 3 [1] | 5 [2] | |
| Other combinations | 4 [1] | 8 [3] |
| . | E coli–asparaginase N = 334 (100%) . | Erwinia-asparaginase N = 319 (100%) . | Odds ratio (95% CI) (P)6-150 . |
|---|---|---|---|
| CR not reached after induction | 12 (3.6) | 21 (6.6) | 1.89 (0.87, 4.29) |
| (.107) | |||
| Remission failure | 4 (1.2) | 12 (3.8) | 3.23 (0.96, 13.84) |
| (.042) | |||
| CR reached | 330 (98.8) | 307 (96.2) | |
| Continuous CR | 242 [73] | 190 [62] | |
| Death in CR | 11 [3] | 7 [2] | |
| Relapses | 77 [23] | 110 [36] | |
| Bone marrow | 45 [14] | 64 [21] | |
| CNS (isolated) | 12 [4] | 18 [6] | |
| CNS (combined) | 13 [4] | 15 [5] | |
| Other isolated | 3 [1] | 5 [2] | |
| Other combinations | 4 [1] | 8 [3] |
Remission failure means patient never achieved CR at the end of induction-consolidation.
Parentheses for columns 2 and 3: percentages were computed on all patients included.
Brackets for columns 2 and 3: percentages were computed on patients having reached CR.
Fisher exact test.