Table 1. EPOCH starting dose level... | American Society of Hematology

Table 1.

EPOCH starting dose level (level 1)

Drug	Dose	Route	Treatment days
Infused agents^*
Etoposide	50 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Doxorubicin	10 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Vincristine^†	0.4 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Bolus agents
Cyclophosphamide	750 mg/m²/day	IV	5
Prednisone	60 mg/m²/bid	Oral	1, 2, 3, 4, 5
G-CSF	5 μg/kg/day	SC	6 to ANC > 5 × 10⁹/L past nadir
Next cycle^‡			Day 21

Drug	Dose	Route	Treatment days
Infused agents^*
Etoposide	50 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Doxorubicin	10 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Vincristine^†	0.4 mg/m²/day	CIV	1, 2, 3, 4 (96 hours)
Bolus agents
Cyclophosphamide	750 mg/m²/day	IV	5
Prednisone	60 mg/m²/bid	Oral	1, 2, 3, 4, 5
G-CSF	5 μg/kg/day	SC	6 to ANC > 5 × 10⁹/L past nadir
Next cycle^‡			Day 21

Etoposide, doxorubicin, and vincristine could be mixed in the same solution.

The vincristine dose was never routinely capped.

Began on day 21 if the ANC was at least 1 × 10⁹/L and the platelet count was at least 100 × 10⁹/L.