Histologic scoring, clinical features, and follow-up
| Case no. . | Age, y/sex . | Site/in situ FL . | Degree of involvement by in situ FL* . | Site/FL . | Months to FL . |
|---|---|---|---|---|---|
| 10 cases with no other evidence of lymphoma | |||||
| 1 | 23/F | Femoral LN | 2/b | — | NEL (96) |
| 2 | 53/F | R axillary LN | 2/a | — | NEL (72) |
| 3 | 63/F | Thyroid | 1/a | — | NEL (58) |
| 4 | 52/F | L axillary LN | 2/b | — | NEL (19) |
| 5 | 28/F | Tonsil/grade III | 1/a | — | NEL (16) |
| 6 | 76/M | R groin LN | 1/a | — | NEL (15) |
| 7 | 37/M | L groin LN | 1/a | — | NEL (7) |
| 8 | 75/F | R axillary LN | 3/b | — | NEL (6) (died of MDS) |
| 9 | 52/F | R cervical LN | 3/b | — | NEL (5) |
| 10 | 41/F | L axillary LN | 1/a | — | NEL (2) median 15.5 |
| 8 cases with subsequent or coexisting FL | |||||
| 11 | 41/M | R axillary LN (1988) | 3/b | Soft tissue, L cheek/FL, grade I (1994) | 72 |
| L neck LN (1992) | 3/b | Paraspinal mass/FL (2000) | |||
| 12 | 55/F | L axillary LN | 3/a | R axillary LN/FL, grade II | 13 |
| 13 | 45/F | R groin LN | 1/a | R groin LN/FL, grade II | 3 |
| 14 | 42/M | R posterior cervical LN | 1/a | R posterior cervical LN/FL, grade II | 0 |
| 15 | 72/M | Cervical LN | 2/b | Parotid mass/FL, grade II | 0 |
| 16 | 55/F | R tonsil | 1/a | L tonsil, FL, grade III | 0 |
| 17 | 65/F | Intralobar LN | 3/b | Lung, FL, grade I | 0 |
| 18 | 58/F | R groin LN | 3/b | L supraclavicular LN/FL, grade II | 0 |
| 5 cases with no available follow-up | |||||
| 19 | 37/F | Retroperitoneal LN | 1/a | — | NA |
| 20 | 68/M | Inguinal LN | 3/b | — | NA |
| 21 | 46/M | Parotid gland | 1/a | — | NA |
| 22 | 44/M | Inguinal LN | 3/a | — | NA |
| 23 | 56/M | LN, site NOS | 3/b | — | NA |
| 2 cases with composite in situ FL and low-grade B-cell lymphoma | |||||
| 24 | 53/M | R & L pelvic LNs | 1/a | CLL/SLL | NA |
| 25 | 63/M | Scalene LN | 2/b | LPL | NA |
| Case no. . | Age, y/sex . | Site/in situ FL . | Degree of involvement by in situ FL* . | Site/FL . | Months to FL . |
|---|---|---|---|---|---|
| 10 cases with no other evidence of lymphoma | |||||
| 1 | 23/F | Femoral LN | 2/b | — | NEL (96) |
| 2 | 53/F | R axillary LN | 2/a | — | NEL (72) |
| 3 | 63/F | Thyroid | 1/a | — | NEL (58) |
| 4 | 52/F | L axillary LN | 2/b | — | NEL (19) |
| 5 | 28/F | Tonsil/grade III | 1/a | — | NEL (16) |
| 6 | 76/M | R groin LN | 1/a | — | NEL (15) |
| 7 | 37/M | L groin LN | 1/a | — | NEL (7) |
| 8 | 75/F | R axillary LN | 3/b | — | NEL (6) (died of MDS) |
| 9 | 52/F | R cervical LN | 3/b | — | NEL (5) |
| 10 | 41/F | L axillary LN | 1/a | — | NEL (2) median 15.5 |
| 8 cases with subsequent or coexisting FL | |||||
| 11 | 41/M | R axillary LN (1988) | 3/b | Soft tissue, L cheek/FL, grade I (1994) | 72 |
| L neck LN (1992) | 3/b | Paraspinal mass/FL (2000) | |||
| 12 | 55/F | L axillary LN | 3/a | R axillary LN/FL, grade II | 13 |
| 13 | 45/F | R groin LN | 1/a | R groin LN/FL, grade II | 3 |
| 14 | 42/M | R posterior cervical LN | 1/a | R posterior cervical LN/FL, grade II | 0 |
| 15 | 72/M | Cervical LN | 2/b | Parotid mass/FL, grade II | 0 |
| 16 | 55/F | R tonsil | 1/a | L tonsil, FL, grade III | 0 |
| 17 | 65/F | Intralobar LN | 3/b | Lung, FL, grade I | 0 |
| 18 | 58/F | R groin LN | 3/b | L supraclavicular LN/FL, grade II | 0 |
| 5 cases with no available follow-up | |||||
| 19 | 37/F | Retroperitoneal LN | 1/a | — | NA |
| 20 | 68/M | Inguinal LN | 3/b | — | NA |
| 21 | 46/M | Parotid gland | 1/a | — | NA |
| 22 | 44/M | Inguinal LN | 3/a | — | NA |
| 23 | 56/M | LN, site NOS | 3/b | — | NA |
| 2 cases with composite in situ FL and low-grade B-cell lymphoma | |||||
| 24 | 53/M | R & L pelvic LNs | 1/a | CLL/SLL | NA |
| 25 | 63/M | Scalene LN | 2/b | LPL | NA |
Each case was scored on bcl-2–stained sections to evaluate the number of bcl-2+ follicles. 1 = < 5 follicles; 2 = 5-10 follicles; 3 = > 10 follicles. Percent of bcl-2+ follicles of total follicles: a = < 50%; b = > 50%.
FL indicates follicular lymphoma; R, right; L, left; NEL, no evidence of lymphoma by means of physical examination, bone marrow biopsy, and whole-body CT-scan; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; and NA, not available.