Risk of myocardial infarction, ischemic stroke, and nonmyocardial infarction–ischemic heart disease in carriers (heterozygotes + homozygotes) of factor V Leiden
| Interaction test stratification . | Myocardial infarction . | Ischemic stroke . | Non-MI ischemic heart disease . | |||
|---|---|---|---|---|---|---|
| Study 1 . | Study 4 . | Study 2 . | Study 5 . | Study 3 . | Study 6 . | |
| Case-control OR . | Prospective RR . | Case-control OR . | Prospective RR . | Case-control OR . | Prospective RR . | |
| Case/control subjects | 493/7907 | 469/8707 | 231/7907 | 410/8835 | 448/7907 | 365/8818 |
| Overall | 1.24 (0.91-1.69) | 0.83 (0.58-1.20) | 0.92 (0.56-1.53) | 0.68 (0.45-1.04) | 1.01 (0.71-1.44) | 0.97 (0.66-1.42) |
| Sex | P = .21 | P = .72 | P = .81 | P = .20 | P = .06 | P = .74 |
| Female | 0.78 (0.34-1.80) | 0.91 (0.51-1.65) | 0.99 (0.45-2.18) | 0.88 (0.51-1.52) | 1.55 (0.92-2.60) | 1.04 (0.60-1.79) |
| Male | 1.34 (0.94-1.90) | 0.80 (0.50-1.27) | 0.88 (0.46-1.72) | 0.51 (0.26-0.99) | 0.77 (0.47-1.24) | 0.91 (0.53-1.54) |
| Age | P = .42 | P = .63 | P = .53 | P = .45 | P = .43 | P = .87 |
| Median or younger | 1.27 (0.83-1.92) | 0.81 (0.47-1.40) | 1.05 (0.54-2.04) | 0.42 (0.20-0.89) | 0.88 (0.52-1.49) | 0.93 (0.53-1.63) |
| Greater than median | 1.21 (0.76-1.93) | 0.85 (0.52-1.39) | 0.79 (0.36-1.71) | 0.96 (0.57-1.59) | 1.04 (0.62-1.73) | 1.01 (0.60-1.72) |
| Smoking | P = .31 | P = .61 | P = .48 | P = .17 | P = .95 | P = .99 |
| No | 0.84 (0.88-3.83) | 0.68 (0.25-1.87) | 1.30 (0.50-3.41) | 1.12 (0.51-2.43) | 1.03 (0.51-2.10) | 0.99 (0.40-2.48) |
| Yes | 1.19 (0.84-1.69) | 0.88 (0.60-1.30) | 0.86 (0.47-1.56) | 0.55 (0.33-0.93) | 1.03 (0.67-1.57) | 0.99 (0.64-1.51) |
| Hypertension | P = .07 | P = .80 | P = .07 | P = .53 | P = .68 | P = .56 |
| No | 1.46 (1.02-2.08) | 0.85 (0.54-1.34) | 0.51 (0.21-1.26) | 0.75 (0.44-1.26) | 1.04 (0.68-1.59) | 1.03 (0.65-1.65) |
| Yes | 0.73 (0.38-1.40) | 0.77 (0.42-1.42) | 1.37 (0.73-2.60) | 0.57 (0.28-1.16) | 0.87 (0.45-1.67) | 0.82 (0.42-1.62) |
| Diabetes mellitus | P = .76 | P = .96 | P = .35 | P = .74 | P = .74 | P = .12 |
| No | 1.25 (0.90-1.74) | 0.85 (0.58-1.24) | 1.03 (0.61-1.73) | 0.68 (0.44-1.06) | 0.99 (0.68-1.43) | 1.03 (0.70-1.52) |
| Yes | 1.01 (0.34-3.01) | 0.78 (0.19-3.25) | 0.36 (0.05-2.87) | 0.48 (0.07-3.48) | 1.12 (0.34-0.39) | — |
| Body mass index | P = .40 | P = .21 | P = .67 | P = .56 | P = .13 | P = .31 |
| Median or less | 1.38 (0.84-2.28) | 1.08 (0.64-1.84) | 0.77 (0.33-1.78) | 0.58 (0.30-1.13) | 0.52 (0.24-1.13) | 1.17 (0.67-2.03) |
| Greater than median | 1.06 (0.68-1.64) | 0.69 (0.41-1.14) | 0.97 (0.48-1.93) | 0.76 (0.44-1.31) | 1.03 (0.63-1.67) | 0.81 (0.47-1.39) |
| Cholesterol | P = .64 | P = .60 | P = .58 | P = .18 | P = .89 | P = .62 |
| Median or less | 1.17 (0.72-1.89) | 0.73 (0.40-1.34) | 1.06 (0.48-2.33) | 0.45 (0.20-1.01) | 0.92 (0.53-1.62) | 1.08 (0.61-1.90) |
| Greater than median | 1.38 (0.89-2.14) | 0.90 (0.57-1.42) | 0.71 (0.34-1.48) | 0.84 (0.51-1.38) | 0.88 (0.51-1.51) | 0.90 (0.53-1.52) |
| HDL cholesterol | P = .35 | P = .50 | P = .37 | P = .51 | P = .53 | P = .17 |
| Median or less | 1.15 (0.81-1.64) | 0.89 (0.59-1.35) | 0.54 (0.25-1.18) | 0.61 (0.35-1.06) | 0.80 (0.51-1.26) | 1.19 (0.75-1.88) |
| Greater than median | 1.82 (0.76-4.34) | 0.67 (0.31-1.43) | 1.49 (0.70-3.14) | 0.78 (0.41-1.49) | 1.10 (0.47-2.57) | 0.66 (0.32-1.34) |
| Triglycerides | P = .05 | P = .25 | P = .75 | P = .11 | P = .27 | P = .50 |
| Median or less | 1.86 (1.14-3.03) | 1.10 (0.61-1.99) | 0.98 (0.42-2.27) | 0.38 (0.16-0.93) | 1.29 (0.73-2.27) | 1.09 (0.62-1.93) |
| Greater than median | 0.97 (0.64-1.45) | 0.71 (0.45-1.13) | 0.73 (0.36-1.45) | 0.86 (0.53-1.39) | 0.86 (0.54-1.35) | 0.86 (0.51-1.46) |
| Lipoprotein(a) | P = .83 | P = .36 | P = .31 | P = .41 | P = .22 | P = .32 |
| Median or less | 1.19 (0.65-2.18) | 0.68 (0.37-1.24) | 0.68 (0.21-2.20) | 0.55 (0.27-1.11) | 1.39 (0.78-2.45) | 0.77 (0.41-1.45) |
| Greater than median | 1.27 (0.88-1.85) | 0.96 (0.61-1.52) | 1.03 (0.47-2.27) | 0.79 (0.47-1.34) | 0.88 (0.56-1.38) | 1.15 (0.71-1.88) |
| Fibrinogen | P = .80 | P = .92 | P= .81 | |||
| Median or less | — | 0.86 (0.45-1.63) | — | 0.68 (0.32-1.46) | — | 0.89 (0.47-1.70) |
| Greater than median | — | 0.79 (0.50-1.25) | — | 0.74 (0.44-1.22) | — | 1.00 (0.61-1.64) |
| Interaction test stratification . | Myocardial infarction . | Ischemic stroke . | Non-MI ischemic heart disease . | |||
|---|---|---|---|---|---|---|
| Study 1 . | Study 4 . | Study 2 . | Study 5 . | Study 3 . | Study 6 . | |
| Case-control OR . | Prospective RR . | Case-control OR . | Prospective RR . | Case-control OR . | Prospective RR . | |
| Case/control subjects | 493/7907 | 469/8707 | 231/7907 | 410/8835 | 448/7907 | 365/8818 |
| Overall | 1.24 (0.91-1.69) | 0.83 (0.58-1.20) | 0.92 (0.56-1.53) | 0.68 (0.45-1.04) | 1.01 (0.71-1.44) | 0.97 (0.66-1.42) |
| Sex | P = .21 | P = .72 | P = .81 | P = .20 | P = .06 | P = .74 |
| Female | 0.78 (0.34-1.80) | 0.91 (0.51-1.65) | 0.99 (0.45-2.18) | 0.88 (0.51-1.52) | 1.55 (0.92-2.60) | 1.04 (0.60-1.79) |
| Male | 1.34 (0.94-1.90) | 0.80 (0.50-1.27) | 0.88 (0.46-1.72) | 0.51 (0.26-0.99) | 0.77 (0.47-1.24) | 0.91 (0.53-1.54) |
| Age | P = .42 | P = .63 | P = .53 | P = .45 | P = .43 | P = .87 |
| Median or younger | 1.27 (0.83-1.92) | 0.81 (0.47-1.40) | 1.05 (0.54-2.04) | 0.42 (0.20-0.89) | 0.88 (0.52-1.49) | 0.93 (0.53-1.63) |
| Greater than median | 1.21 (0.76-1.93) | 0.85 (0.52-1.39) | 0.79 (0.36-1.71) | 0.96 (0.57-1.59) | 1.04 (0.62-1.73) | 1.01 (0.60-1.72) |
| Smoking | P = .31 | P = .61 | P = .48 | P = .17 | P = .95 | P = .99 |
| No | 0.84 (0.88-3.83) | 0.68 (0.25-1.87) | 1.30 (0.50-3.41) | 1.12 (0.51-2.43) | 1.03 (0.51-2.10) | 0.99 (0.40-2.48) |
| Yes | 1.19 (0.84-1.69) | 0.88 (0.60-1.30) | 0.86 (0.47-1.56) | 0.55 (0.33-0.93) | 1.03 (0.67-1.57) | 0.99 (0.64-1.51) |
| Hypertension | P = .07 | P = .80 | P = .07 | P = .53 | P = .68 | P = .56 |
| No | 1.46 (1.02-2.08) | 0.85 (0.54-1.34) | 0.51 (0.21-1.26) | 0.75 (0.44-1.26) | 1.04 (0.68-1.59) | 1.03 (0.65-1.65) |
| Yes | 0.73 (0.38-1.40) | 0.77 (0.42-1.42) | 1.37 (0.73-2.60) | 0.57 (0.28-1.16) | 0.87 (0.45-1.67) | 0.82 (0.42-1.62) |
| Diabetes mellitus | P = .76 | P = .96 | P = .35 | P = .74 | P = .74 | P = .12 |
| No | 1.25 (0.90-1.74) | 0.85 (0.58-1.24) | 1.03 (0.61-1.73) | 0.68 (0.44-1.06) | 0.99 (0.68-1.43) | 1.03 (0.70-1.52) |
| Yes | 1.01 (0.34-3.01) | 0.78 (0.19-3.25) | 0.36 (0.05-2.87) | 0.48 (0.07-3.48) | 1.12 (0.34-0.39) | — |
| Body mass index | P = .40 | P = .21 | P = .67 | P = .56 | P = .13 | P = .31 |
| Median or less | 1.38 (0.84-2.28) | 1.08 (0.64-1.84) | 0.77 (0.33-1.78) | 0.58 (0.30-1.13) | 0.52 (0.24-1.13) | 1.17 (0.67-2.03) |
| Greater than median | 1.06 (0.68-1.64) | 0.69 (0.41-1.14) | 0.97 (0.48-1.93) | 0.76 (0.44-1.31) | 1.03 (0.63-1.67) | 0.81 (0.47-1.39) |
| Cholesterol | P = .64 | P = .60 | P = .58 | P = .18 | P = .89 | P = .62 |
| Median or less | 1.17 (0.72-1.89) | 0.73 (0.40-1.34) | 1.06 (0.48-2.33) | 0.45 (0.20-1.01) | 0.92 (0.53-1.62) | 1.08 (0.61-1.90) |
| Greater than median | 1.38 (0.89-2.14) | 0.90 (0.57-1.42) | 0.71 (0.34-1.48) | 0.84 (0.51-1.38) | 0.88 (0.51-1.51) | 0.90 (0.53-1.52) |
| HDL cholesterol | P = .35 | P = .50 | P = .37 | P = .51 | P = .53 | P = .17 |
| Median or less | 1.15 (0.81-1.64) | 0.89 (0.59-1.35) | 0.54 (0.25-1.18) | 0.61 (0.35-1.06) | 0.80 (0.51-1.26) | 1.19 (0.75-1.88) |
| Greater than median | 1.82 (0.76-4.34) | 0.67 (0.31-1.43) | 1.49 (0.70-3.14) | 0.78 (0.41-1.49) | 1.10 (0.47-2.57) | 0.66 (0.32-1.34) |
| Triglycerides | P = .05 | P = .25 | P = .75 | P = .11 | P = .27 | P = .50 |
| Median or less | 1.86 (1.14-3.03) | 1.10 (0.61-1.99) | 0.98 (0.42-2.27) | 0.38 (0.16-0.93) | 1.29 (0.73-2.27) | 1.09 (0.62-1.93) |
| Greater than median | 0.97 (0.64-1.45) | 0.71 (0.45-1.13) | 0.73 (0.36-1.45) | 0.86 (0.53-1.39) | 0.86 (0.54-1.35) | 0.86 (0.51-1.46) |
| Lipoprotein(a) | P = .83 | P = .36 | P = .31 | P = .41 | P = .22 | P = .32 |
| Median or less | 1.19 (0.65-2.18) | 0.68 (0.37-1.24) | 0.68 (0.21-2.20) | 0.55 (0.27-1.11) | 1.39 (0.78-2.45) | 0.77 (0.41-1.45) |
| Greater than median | 1.27 (0.88-1.85) | 0.96 (0.61-1.52) | 1.03 (0.47-2.27) | 0.79 (0.47-1.34) | 0.88 (0.56-1.38) | 1.15 (0.71-1.88) |
| Fibrinogen | P = .80 | P = .92 | P= .81 | |||
| Median or less | — | 0.86 (0.45-1.63) | — | 0.68 (0.32-1.46) | — | 0.89 (0.47-1.70) |
| Greater than median | — | 0.79 (0.50-1.25) | — | 0.74 (0.44-1.22) | — | 1.00 (0.61-1.64) |
Values represent odds ratios (OR) and relative risks (RR) with 95% confidence intervals. Calculations are based on slightly varying numbers according to availability of data for each covariate.
All continuous variables, except for age, were stratified according to the median determined in the control group; these medians were body mass index 25 kg/m2, cholesterol 6.1 mM, HDL cholesterol 1.5 mM, lipoprotein(a) 173 mg/dL, triglycerides 1.5 mM, fibrinogen 3.0 mg/dL. For age, the median was determined among case subjects in the relevant study. Age medians were 59, 52, 64, 55, 59, and 55 years in studies 1 through 6, respectively.
MI indicates myocardial infarction; HDL, high-density lipoprotein.