Thrombin formation and thrombin substrates
| Substrate . | Initiation phase duration (min) . | Thrombin concentration at the inception point (nM) . | Thrombin levels at the inception point (%) . | Rate of propagation (nM/min) . | Maximum levels of products (nM) . | Product generated (%) . |
|---|---|---|---|---|---|---|
| Osteonectin | 1.9 ± 0.2 | 0.51 ± 0.18 | 0.06 | 6.8 ± 0.4 | 44.6 ± 6.7 | 77 |
| FXIIIa | 2.2 ± 0.6 | 0.84 ± 0.28 | 0.099 | 10.3 ± 0.9 | 56.3 ± 3.4 | 62 |
| (11.4 ± 1.0%/min) | (62.5 ± 3.8%) | |||||
| FV | 2.2 ± 0.4 | 0.84 ± 0.28 | 0.099 | 4.5 ± 1.3 | 12.3 ± 2.1 | 62 |
| (22.4 ± 6.3%/min) | (61.7 ± 10.4%) | |||||
| FPA | 2.5 ± 0.7 | 1.3 ± 0.4 | 0.15 | 2 700 ± 200 | 15 300 ± 1 300 | 100 |
| FPB | 2.8 ± 0.8 | 1.7 ± 0.5 | 0.20 | 1 200 ± 100 | 5 800 ± 600 | 39 |
| Thrombin B chain | 3.6 ± 0.2 | 7.0 ± 2.2 | 0.82 | 56.9 ± 2.1 | 494 ± 66 | 35 |
| TAT | 4.6 ± 0.6 | 26 ± 6.2 | 3.1 | 83.9 ± 3.8 | 851 ± 53 | 61 |
| Substrate . | Initiation phase duration (min) . | Thrombin concentration at the inception point (nM) . | Thrombin levels at the inception point (%) . | Rate of propagation (nM/min) . | Maximum levels of products (nM) . | Product generated (%) . |
|---|---|---|---|---|---|---|
| Osteonectin | 1.9 ± 0.2 | 0.51 ± 0.18 | 0.06 | 6.8 ± 0.4 | 44.6 ± 6.7 | 77 |
| FXIIIa | 2.2 ± 0.6 | 0.84 ± 0.28 | 0.099 | 10.3 ± 0.9 | 56.3 ± 3.4 | 62 |
| (11.4 ± 1.0%/min) | (62.5 ± 3.8%) | |||||
| FV | 2.2 ± 0.4 | 0.84 ± 0.28 | 0.099 | 4.5 ± 1.3 | 12.3 ± 2.1 | 62 |
| (22.4 ± 6.3%/min) | (61.7 ± 10.4%) | |||||
| FPA | 2.5 ± 0.7 | 1.3 ± 0.4 | 0.15 | 2 700 ± 200 | 15 300 ± 1 300 | 100 |
| FPB | 2.8 ± 0.8 | 1.7 ± 0.5 | 0.20 | 1 200 ± 100 | 5 800 ± 600 | 39 |
| Thrombin B chain | 3.6 ± 0.2 | 7.0 ± 2.2 | 0.82 | 56.9 ± 2.1 | 494 ± 66 | 35 |
| TAT | 4.6 ± 0.6 | 26 ± 6.2 | 3.1 | 83.9 ± 3.8 | 851 ± 53 | 61 |