Tumor growth in the SCID-hu host
| . | No. of animals injected* . | No. of animals with tumor . | Change in diameter, cm . | Wet weight, g . |
|---|---|---|---|---|
| Neo | 7 | 6 | 0.34 ± 0.09 | 1.72 ± 0.54 |
| Syn-1 | 5 | 1 | 0.22 ± 0.22 | 0.83 ± 0.53† |
| sSyn-1 | 6 | 6 | 0.72 ± 0.21 | 2.98 ± 0.68† |
| . | No. of animals injected* . | No. of animals with tumor . | Change in diameter, cm . | Wet weight, g . |
|---|---|---|---|---|
| Neo | 7 | 6 | 0.34 ± 0.09 | 1.72 ± 0.54 |
| Syn-1 | 5 | 1 | 0.22 ± 0.22 | 0.83 ± 0.53† |
| sSyn-1 | 6 | 6 | 0.72 ± 0.21 | 2.98 ± 0.68† |
No. of animals with tumor (at 8 weeks after injection) represents the number of animals with detectable levels of human kappa light chain, an indicator of the presence of active tumor. Change of diameter reflects the increase in mean tumor diameter during the 8-week growth period. Diameter of bones was measured prior to injection of tumor cells, and the diameter of tumor including bone was measured just prior to harvesting the tumor. At the time of harvest, 8 weeks after injection of tumor cells, the tumors usually have infiltrated and overgrown the bone. Wet weight is the mean weight of the remaining bone and any associated tumor. The data for diameter and weight represent the mean from all animals in each group ± SE. SCID-hu, human fetal bones implanted in severe combined immunodeficient mice; Neo, vector only; Syn-1, syndecan-1; sSyn-1, soluble syndecan-1.
Animal numbers are lower than shown in Figure 7 because in this initial experiment animals were killed after 8 weeks. Subsequent experiments were carried out for longer periods to assess tumor dissemination, making it impossible to obtain wet weights of the primary tumors at week 8.
P < .05.