Table 1. Factor XIII substrates... | American Society of Hematology

Table 1.

Factor XIII substrates

Substrate	Cross-linking site	Substances with which it is cross-linked	Known or potential function
Fibrin(ogen) γ-chain52-54	Gln398, Gln399, and Lys406	Itself and α-chain	Clot stabilization
Fibrin(ogen) α-chain58-62	Gln221, Gln237, Gln328, Gln366, and 15 potential lysines from Lys208 to Lys606	Itself and γ-chain	Clot stabilization
α2-Antiplasmin67-69	Gln2	Lys303 fibrin α-chain	Resistance to fibrinolysis
TAFI¹⁵⁰	Gln2, Gln5, Gln292	Fibrin, itself	Resistance to fibrinolysis
PAI-2151 152	—	Lys148, Lys230, Lys413 fibrin α-chain	Resistance to fibrinolysis
Fibronectin72 73	Gln3	Itself, fibrin, collagen	Migration of cells into the clot; wound healing
Collagen72 80	—	Fibronectin, fibrin	Stabilization of extracellular matrix
Von Willebrand factor153 154	—	Fibrin, collagen	Platelet adhesion to the clot
Vitronectin155 156	Gln93	—	—
Thrombospondin¹⁵⁷	—	Fibrin	—
Factor V158 159	—	Fibrin, platelets	Increased thrombin generation at the clot surface
Actin160 161	—	Fibrin	Clot retraction, stabilization of the platelet cytoskeleton
Myosin¹⁶²	—	Itself	Clot retraction, stabilization of the platelet cytoskeleton
Vinculin¹⁶³	—	Fibrin	Clot retraction, stabilization of the platelet cytoskeleton
α_IIbβ₃¹⁶⁴	—	Fibrin	Stabilization of the platelet—fibrin clot

Substrate	Cross-linking site	Substances with which it is cross-linked	Known or potential function
Fibrin(ogen) γ-chain52-54	Gln398, Gln399, and Lys406	Itself and α-chain	Clot stabilization
Fibrin(ogen) α-chain58-62	Gln221, Gln237, Gln328, Gln366, and 15 potential lysines from Lys208 to Lys606	Itself and γ-chain	Clot stabilization
α2-Antiplasmin67-69	Gln2	Lys303 fibrin α-chain	Resistance to fibrinolysis
TAFI¹⁵⁰	Gln2, Gln5, Gln292	Fibrin, itself	Resistance to fibrinolysis
PAI-2151 152	—	Lys148, Lys230, Lys413 fibrin α-chain	Resistance to fibrinolysis
Fibronectin72 73	Gln3	Itself, fibrin, collagen	Migration of cells into the clot; wound healing
Collagen72 80	—	Fibronectin, fibrin	Stabilization of extracellular matrix
Von Willebrand factor153 154	—	Fibrin, collagen	Platelet adhesion to the clot
Vitronectin155 156	Gln93	—	—
Thrombospondin¹⁵⁷	—	Fibrin	—
Factor V158 159	—	Fibrin, platelets	Increased thrombin generation at the clot surface
Actin160 161	—	Fibrin	Clot retraction, stabilization of the platelet cytoskeleton
Myosin¹⁶²	—	Itself	Clot retraction, stabilization of the platelet cytoskeleton
Vinculin¹⁶³	—	Fibrin	Clot retraction, stabilization of the platelet cytoskeleton
α_IIbβ₃¹⁶⁴	—	Fibrin	Stabilization of the platelet—fibrin clot

TAFI indicates thrombin-activatable fibrinolysis inhibitor; PAI-2, plasminogen activator inhibitor 2.