Associations between MBL2 coding mutations and major infection after transplantation
| Sample group . | No. with coding mutation . | No. without coding mutation . | Major infection when mutation is present, no. (%) . | Major infection when mutation is absent, no. (%) . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|
| Donor, n = 90 | 38 | 52 | 29 (76) | 23 (44) | .002 | 4.1 (1.6-10.3) |
| Recipient, n = 93 | 38 | 55 | 26 (68) | 25 (45) | .04 | 2.6 (1.1-6.3) |
| Donor or recipient, n = 87 | 52 | 35 | 36 (69) | 18 (41) | .007 | 3.1 (1.3-7.3) |
| Donor and recipient, n = 87 | 24 | 63 | 19 (79) | 32 (50) | .01 | 3.7 (1.2-11.1) |
| Sample group . | No. with coding mutation . | No. without coding mutation . | Major infection when mutation is present, no. (%) . | Major infection when mutation is absent, no. (%) . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|
| Donor, n = 90 | 38 | 52 | 29 (76) | 23 (44) | .002 | 4.1 (1.6-10.3) |
| Recipient, n = 93 | 38 | 55 | 26 (68) | 25 (45) | .04 | 2.6 (1.1-6.3) |
| Donor or recipient, n = 87 | 52 | 35 | 36 (69) | 18 (41) | .007 | 3.1 (1.3-7.3) |
| Donor and recipient, n = 87 | 24 | 63 | 19 (79) | 32 (50) | .01 | 3.7 (1.2-11.1) |
This table details the analyses showing significant positive associations between the presence of MBL2 coding mutations and risk of major infection after SCT. Infection frequencies refer to number of recipients experiencing an episode of major infection—not the number of episodes of infection. The codon 52, 54, and 57 mutations have been grouped together for this analysis because they have similar effects on MBL levels. The associations between MBL2mutations and infection were seen with donor and recipientMBL2 genotype.