MBL2 polymorphism associations with bacterial infections
| MBL variant . | Sample group, total no. in group . | Total no. with variant . | Bacterial infection when variant is present, no. (%) . | Bacterial infection when variant is absent, no. (%) . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|
| Coding mutation | Donor, n = 90 | 38 | 29 (76) | 23 (44) | .002 | 4.1 (1.6-10.3) |
| Recipient, n = 93 | 38 | 27 (71) | 27 (49) | .04 | 2.4 (1.1-6.3) | |
| HYA haplotype | Donor, n = 90 | 54 | 25 (46) | 30 (81) | .0008 | 0.2 (0.08-0.54) |
| Recipient, n = 93 | 56 | 26 (46) | 30 (79) | .001 | 0.23 (0.09-0.59) |
| MBL variant . | Sample group, total no. in group . | Total no. with variant . | Bacterial infection when variant is present, no. (%) . | Bacterial infection when variant is absent, no. (%) . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|
| Coding mutation | Donor, n = 90 | 38 | 29 (76) | 23 (44) | .002 | 4.1 (1.6-10.3) |
| Recipient, n = 93 | 38 | 27 (71) | 27 (49) | .04 | 2.4 (1.1-6.3) | |
| HYA haplotype | Donor, n = 90 | 54 | 25 (46) | 30 (81) | .0008 | 0.2 (0.08-0.54) |
| Recipient, n = 93 | 56 | 26 (46) | 30 (79) | .001 | 0.23 (0.09-0.59) |
MBL2 coding mutations and the HYA haplotype, when present in either donor or recipient, are associated with the occurrence of bacterial infection after SCT.