Table 2.

Patient age at diagnosis and summary of backtrackingAML1-ETO genomic fusions in childhood acute myeloid leukemia

Study no.Age at diagnosis, y, moGuthrie segments testedGuthrie segments positivePositive
or negative*
3, 6 12 +  
3, 11 +  
4, 11 12 −  
5, 2 12 −  
6, 3 +  
7, 9 12 −  
8, 7 12 −  
10, 0 10 −  
10, 1 12 +  
10 12, 2 12 
Study no.Age at diagnosis, y, moGuthrie segments testedGuthrie segments positivePositive
or negative*
3, 6 12 +  
3, 11 +  
4, 11 12 −  
5, 2 12 −  
6, 3 +  
7, 9 12 −  
8, 7 12 −  
10, 0 10 −  
10, 1 12 +  
10 12, 2 12 
*

A plus sign indicates the presence of clonotypicAML1-ETO in the Guthrie card; a minus sign indicates the lack of demonstrable clonotypic translocation sequence, which is indeterminate for prenatal origin.

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