Frequency distribution of clinical and biologic features with respect to MDR1 expression
| . | MDR1 positive . | MDR1 negative . | ||
|---|---|---|---|---|
| No. . | % . | No. . | % . | |
| Age (y) | ||||
| 16-30 | 79/100 | 79.0 | 21/100 | 21.0 |
| 31-50 | 56/73 | 76.7 | 17/73 | 23.3 |
| 51-60 | 24/30 | 80.0 | 6/30 | 20.0 |
| WBC (× 109/L) | ||||
| < 10 | 60/75 | 80.0 | 15/75 | 20.0 |
| 11-30 | 33/44 | 75.0 | 11/44 | 25.0 |
| 31-50 | 15/18 | 83.3 | 3/18 | 16.7 |
| 51-100 | 23/28 | 82.1 | 5/28 | 17.9 |
| > 100 | 27/37 | 73.0 | 10/37 | 27.0 |
| Immunophenotype | ||||
| B-ALL | 127/160 | 79.4 | 33/160 | 20.6 |
| T-ALL | 32/43 | 74.4 | 11/43 | 25.6 |
| CD34− | 52/64 | 81.3 | 12/64 | 18.7 |
| CD34+ | 103/134 | 76.9 | 31/134 | 23.1 |
| CD33− | 121/150 | 80.7 | 29/150 | 19.3 |
| CD33+ | 28/40 | 70.0 | 12/40 | 30.0 |
| CD10− | 48/62 | 77.4 | 14/62 | 22.6 |
| CD10+ | 104/132 | 78.8 | 28/132 | 21.2 |
| Cytogenetics | ||||
| Normal karyotype | 41/53 | 77.4 | 12/53 | 22.6 |
| t(9;22) ± others | 27/33 | 81.8 | 6/33 | 18.2 |
| t(4;11) ± others | 11/11 | 100.0 | 0/11 | 0.0 |
| del (6q) ± others | 8/8 | 100.0 | 0/8 | 0.0 |
| del (7q) ± others | 2/3 | 66.7 | 1/3 | 33.3 |
| t(1;19) ± others | 2/2 | 100.0 | 0/2 | 0.0 |
| Other abnormalities | 12/19 | 63.2 | 7/19 | 36.8 |
| > 3 abnormalities | 7/13 | 53.9 | 6/13 | 46.1 |
| Failure | 43/53 | 81.1 | 10/53 | 18.9 |
| Molecular genetics | ||||
| BCR/ABL− | 115/148 | 77.7 | 33/148 | 22.3 |
| BCR/ABL+ | 43/51 | 84.3 | 8/51 | 15.7 |
| t (4;11)− | 131/169 | 77.5 | 38/169 | 22.5 |
| t (4;11)+ | 13/13 | 100.0 | 0/13 | 0.0 |
| . | MDR1 positive . | MDR1 negative . | ||
|---|---|---|---|---|
| No. . | % . | No. . | % . | |
| Age (y) | ||||
| 16-30 | 79/100 | 79.0 | 21/100 | 21.0 |
| 31-50 | 56/73 | 76.7 | 17/73 | 23.3 |
| 51-60 | 24/30 | 80.0 | 6/30 | 20.0 |
| WBC (× 109/L) | ||||
| < 10 | 60/75 | 80.0 | 15/75 | 20.0 |
| 11-30 | 33/44 | 75.0 | 11/44 | 25.0 |
| 31-50 | 15/18 | 83.3 | 3/18 | 16.7 |
| 51-100 | 23/28 | 82.1 | 5/28 | 17.9 |
| > 100 | 27/37 | 73.0 | 10/37 | 27.0 |
| Immunophenotype | ||||
| B-ALL | 127/160 | 79.4 | 33/160 | 20.6 |
| T-ALL | 32/43 | 74.4 | 11/43 | 25.6 |
| CD34− | 52/64 | 81.3 | 12/64 | 18.7 |
| CD34+ | 103/134 | 76.9 | 31/134 | 23.1 |
| CD33− | 121/150 | 80.7 | 29/150 | 19.3 |
| CD33+ | 28/40 | 70.0 | 12/40 | 30.0 |
| CD10− | 48/62 | 77.4 | 14/62 | 22.6 |
| CD10+ | 104/132 | 78.8 | 28/132 | 21.2 |
| Cytogenetics | ||||
| Normal karyotype | 41/53 | 77.4 | 12/53 | 22.6 |
| t(9;22) ± others | 27/33 | 81.8 | 6/33 | 18.2 |
| t(4;11) ± others | 11/11 | 100.0 | 0/11 | 0.0 |
| del (6q) ± others | 8/8 | 100.0 | 0/8 | 0.0 |
| del (7q) ± others | 2/3 | 66.7 | 1/3 | 33.3 |
| t(1;19) ± others | 2/2 | 100.0 | 0/2 | 0.0 |
| Other abnormalities | 12/19 | 63.2 | 7/19 | 36.8 |
| > 3 abnormalities | 7/13 | 53.9 | 6/13 | 46.1 |
| Failure | 43/53 | 81.1 | 10/53 | 18.9 |
| Molecular genetics | ||||
| BCR/ABL− | 115/148 | 77.7 | 33/148 | 22.3 |
| BCR/ABL+ | 43/51 | 84.3 | 8/51 | 15.7 |
| t (4;11)− | 131/169 | 77.5 | 38/169 | 22.5 |
| t (4;11)+ | 13/13 | 100.0 | 0/13 | 0.0 |