Cytogenetic findings in follicular lymphomas
| Morphology (n > 8 of 89) . | FL 1 . | FL 2 . | FL 3a . | P FL1 and 2 vs FL 3a . | FL 3b . | FL 3b + DLBL . | FL 3b ± DLBL . | P FL 1-3a vs FL 3b ± DLBL . | P FL 3a vs FL 3b ± DLBL . |
|---|---|---|---|---|---|---|---|---|---|
| Total | 4.1 | 4.3 | 6.5 | < .06 (< .67) | 8.0 | 9.3 | 8.9 | < .0001 | < .06 (< .01) |
| Structural | 2.0 | 2.3 | 3.7 | < .01 (< .83) | 5.0 | 4.5 | 4.6 | < .0001 | < .19 (< .001) |
| Numerical | 2.0 | 1.9 | 2.7 | < .35 | 3.0 | 4.8 | 4.3 | < .001 | < .09 |
| t(14;18) (%) | 25/29 | 28/33 | 8/11 | < .30 | 0/4 | 2/12 | 2/16 | < .0001 | < .01 |
| (86) | (85) | (73) | (0) | (17) | (13) | ||||
| BP 3q27 (%) | 1/29 | 1/33 | 2/11 | < .05 (< .11) | 0/4 | 7/12 | 7/16 | < .0001 | < .17 |
| (3) | (3) | (18) | (0) | (58) | (44) | ||||
| + 1q (%) | 2/29 | 5/33 | 0/11 | < .24 | 3/4 | 4/12 | 7/16 | < .001 | < .02 (< .07) |
| (7) | (15) | (0) | (75) | (33) | (44) | ||||
| − 1p (%) | 1/29 | 2/33 | 4/11 | < .01 (< .45) | 1/4 | 2/12 | 3/16 | < .30 | < .31 |
| (3) | (6) | (36) | (25) | (17) | (19) | ||||
| + 5/5q (%) | 2/29 | 3/33 | 2/11 | < .30 (< .02) | 0/4 | 3/12 | 3/16 | < .30 | < .98 |
| (7) | (9) | (18) | (0) | (25) | (19) | ||||
| − 6q (%) | 7/29 | 5/33 | 4/11 | < .21 | 2/4 | 6/12 | 8/16 | < .03 | < .49 |
| (24) | (15) | (36) | (50) | (50) | (50) | ||||
| + 6p (%) | 3/29 | 4/33 | 1/11 | < .83 | 1/4 | 2/12 | 3/16 | < .40 | < .49 |
| (10) | (12) | (9) | (25) | (17) | (19) | ||||
| + 7 (%) | 3/29 | 11/33 | 1/11 | < .31 | 1/4 | 1/12 | 2/16 | < .46 | < .79 |
| (10) | (33) | (9) | (25) | (8) | (13) | ||||
| − 10q (%) | 3/29 | 4/33 | 1/11 | < .83 | 0/4 | 2/12 | 2/16 | < .57 | < .79 |
| (10) | (12) | (9) | (0) | (17) | (13) | ||||
| + 12/12q (%) | 4/29 | 7/33 | 3/11 | < .46 | 1/4 | 1/12 | 2/16 | < .53 | < .34 |
| (14) | (21) | (27) | (25) | (8) | (13) | ||||
| + 17q (%) | 3/29 | 1/33 | 1/11 | < .75 | 1/4 | 3/12 | 4/16 | < .03 (< .23) | < .30 |
| (10) | (3) | (9) | (25) | (25) | (25) | ||||
| − 17p (%) | 0/29 | 2/33 | 2/11 | < .05 (< .27) | 1/4 | 4/12 | 5/16 | < .01 | < .45 |
| (0) | (6) | (18) | (25) | (33) | (31) | ||||
| + 18/der(18) t(14;18)(%) | 5/29 | 4/33 | 2/11 | < .76 | 0/4 | 5/12 | 5/16 | < .13 | < .46 |
| (17) | (12) | (18) | (0) | (42) | (31) | ||||
| + X (%) | 6/29 | 3/33 | 2/11 | < .76 | 0/4 | 4/12 | 4/16 | < .34 | < .68 |
| (21) | (10) | (18) | (0) | (33) | (25) |
| Morphology (n > 8 of 89) . | FL 1 . | FL 2 . | FL 3a . | P FL1 and 2 vs FL 3a . | FL 3b . | FL 3b + DLBL . | FL 3b ± DLBL . | P FL 1-3a vs FL 3b ± DLBL . | P FL 3a vs FL 3b ± DLBL . |
|---|---|---|---|---|---|---|---|---|---|
| Total | 4.1 | 4.3 | 6.5 | < .06 (< .67) | 8.0 | 9.3 | 8.9 | < .0001 | < .06 (< .01) |
| Structural | 2.0 | 2.3 | 3.7 | < .01 (< .83) | 5.0 | 4.5 | 4.6 | < .0001 | < .19 (< .001) |
| Numerical | 2.0 | 1.9 | 2.7 | < .35 | 3.0 | 4.8 | 4.3 | < .001 | < .09 |
| t(14;18) (%) | 25/29 | 28/33 | 8/11 | < .30 | 0/4 | 2/12 | 2/16 | < .0001 | < .01 |
| (86) | (85) | (73) | (0) | (17) | (13) | ||||
| BP 3q27 (%) | 1/29 | 1/33 | 2/11 | < .05 (< .11) | 0/4 | 7/12 | 7/16 | < .0001 | < .17 |
| (3) | (3) | (18) | (0) | (58) | (44) | ||||
| + 1q (%) | 2/29 | 5/33 | 0/11 | < .24 | 3/4 | 4/12 | 7/16 | < .001 | < .02 (< .07) |
| (7) | (15) | (0) | (75) | (33) | (44) | ||||
| − 1p (%) | 1/29 | 2/33 | 4/11 | < .01 (< .45) | 1/4 | 2/12 | 3/16 | < .30 | < .31 |
| (3) | (6) | (36) | (25) | (17) | (19) | ||||
| + 5/5q (%) | 2/29 | 3/33 | 2/11 | < .30 (< .02) | 0/4 | 3/12 | 3/16 | < .30 | < .98 |
| (7) | (9) | (18) | (0) | (25) | (19) | ||||
| − 6q (%) | 7/29 | 5/33 | 4/11 | < .21 | 2/4 | 6/12 | 8/16 | < .03 | < .49 |
| (24) | (15) | (36) | (50) | (50) | (50) | ||||
| + 6p (%) | 3/29 | 4/33 | 1/11 | < .83 | 1/4 | 2/12 | 3/16 | < .40 | < .49 |
| (10) | (12) | (9) | (25) | (17) | (19) | ||||
| + 7 (%) | 3/29 | 11/33 | 1/11 | < .31 | 1/4 | 1/12 | 2/16 | < .46 | < .79 |
| (10) | (33) | (9) | (25) | (8) | (13) | ||||
| − 10q (%) | 3/29 | 4/33 | 1/11 | < .83 | 0/4 | 2/12 | 2/16 | < .57 | < .79 |
| (10) | (12) | (9) | (0) | (17) | (13) | ||||
| + 12/12q (%) | 4/29 | 7/33 | 3/11 | < .46 | 1/4 | 1/12 | 2/16 | < .53 | < .34 |
| (14) | (21) | (27) | (25) | (8) | (13) | ||||
| + 17q (%) | 3/29 | 1/33 | 1/11 | < .75 | 1/4 | 3/12 | 4/16 | < .03 (< .23) | < .30 |
| (10) | (3) | (9) | (25) | (25) | (25) | ||||
| − 17p (%) | 0/29 | 2/33 | 2/11 | < .05 (< .27) | 1/4 | 4/12 | 5/16 | < .01 | < .45 |
| (0) | (6) | (18) | (25) | (33) | (31) | ||||
| + 18/der(18) t(14;18)(%) | 5/29 | 4/33 | 2/11 | < .76 | 0/4 | 5/12 | 5/16 | < .13 | < .46 |
| (17) | (12) | (18) | (0) | (42) | (31) | ||||
| + X (%) | 6/29 | 3/33 | 2/11 | < .76 | 0/4 | 4/12 | 4/16 | < .34 | < .68 |
| (21) | (10) | (18) | (0) | (33) | (25) |
P values refer to all cases analyzed. Pvalues in brackets and italics, referring to untreated cases exclusively, are given only if significance levels changed. Mean values are given for total, structural, and numerical aberrations.