Genes up-regulated during ATRA/IL-3–induced EML cell differentiation
| Symbol . | Name . | Gene Ontology . |
|---|---|---|
| Gzmb | C11 encoding T-cell–specific protein CCPI CTLA-1, granzyme B | Apoptosis |
| Prg2 | Proteoglycan 2, esoinophil major basic protein | Apoptosis |
| Dad1 | Defender against cell death 1 | Apoptosis |
| Bnip3l | BCL2/adenovirus E1B 19-kd interacting protein 3-like | Apoptosis |
| Tial1 | Tial1 cytotoxic granule-associated RNA-binding protein-like 1 | Apoptosis |
| Calm | Calmodulin | Calcium binding |
| Calr | Calreticulin | Calcium binding |
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21) | Cell cycle |
| Ppm1g | Protein phosphatase 1G, magnesium-dependent, γ isoform | Cell cycle |
| LATS1 | Large tumor suppressor homolog 1 | Cell cycle control |
| Ran | GTP-binding nuclear protein RAN, member RAS oncogene family | Cell cycle regulator |
| Mdm2 | Transformed mouse 3T3 cell double minute 2 | Cell growth and maintenance |
| Cct5 | Chaperonin subunit 5 ɛ | Chaperone |
| C1qa | Complement component 1, q subcomponent, α polypeptide | Complement component |
| Myo1c | Myosin Ic | Cytoskeleton organization and biogenesis |
| Ncl | Nucleolin | DNA, RNA binding |
| Madh5 | MAD homolog 5 | Embryogenesis and morphogenesis |
| Mt1 | Metallothionein1 | Heavy metal binding |
| Elavl3 | ELAV-like 3 (Hu antigen C) | Histogenesis and organogenesis |
| Igj | Immunoglobulin joining chain | Humoral defense mechanism |
| Ppia | Peptidylprolyl isomerase A | Immune response |
| Scya19 | Small inducible cytokine A19 | Inflammatory response |
| Itgb7 | Integrin β 7 | Integrin receptor signal signaling pathway |
| Emp3 | Epithelial membrane protein 3 | Membrane fraction |
| Vasp | Vasodilator-stimulated phosphoprotein | Mineralcorticoid metabolism |
| Ada | Adenosine deaminase | Nucleic acid metabolism |
| Ubb | Ubiquitin B | Nucleus |
| Gnas | Guanine nucleotide binding protein, α stimulating | Protein ADP-ribosylation |
| DHPS | Deoxyhypusine synthase | Protein biosynthesis |
| Eef1a1 | Elongation factor 1-alpha (EF 1-α) | Protein biosynthesis |
| Ptpn11 | Protein tyrosine phosphatase, nonreceptor type 11 | Protein tyrosine phosphatase |
| Impdh2 | IMP dehydrogenase | Purine nucleotide biosynthesis |
| Various | Ribosomal proteins L3, L4, L5, L6, L7, L10, L11, L13, L23a, L29 | Ribosome biogenesis |
| Various | Ribosomal proteins S3, S4, S6, S7, S12, S14, S16, S17, S19, S20 | Ribosome biogenesis |
| Fgfr4 | Fibroblast growth factor receptor 4 | Signal transduction |
| Nsp3 | SH2-containing protein 3 | Signal transduction |
| Rgl2 | Ral guanine nucleotide dissociation stimulator-like 2 | Signal transduction |
| Mint | Msx2-interacting nuclear target protein | Transcription factor |
| Mtf2 | Metal response element binding transcription factor 2 | Transcription factor |
| Bteb3 | Basic transcription element binding protein 3 | Transcription from Pol II promoter |
| Klf9 | Kruppel-like factor 9 | Transcription regulation |
| Creg | Cellular repressor of E1A-stimulated genes | Transcription regulation |
| Rb1 | Retinoblastoma 1 | Transcription regulation |
| Symbol . | Name . | Gene Ontology . |
|---|---|---|
| Gzmb | C11 encoding T-cell–specific protein CCPI CTLA-1, granzyme B | Apoptosis |
| Prg2 | Proteoglycan 2, esoinophil major basic protein | Apoptosis |
| Dad1 | Defender against cell death 1 | Apoptosis |
| Bnip3l | BCL2/adenovirus E1B 19-kd interacting protein 3-like | Apoptosis |
| Tial1 | Tial1 cytotoxic granule-associated RNA-binding protein-like 1 | Apoptosis |
| Calm | Calmodulin | Calcium binding |
| Calr | Calreticulin | Calcium binding |
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21) | Cell cycle |
| Ppm1g | Protein phosphatase 1G, magnesium-dependent, γ isoform | Cell cycle |
| LATS1 | Large tumor suppressor homolog 1 | Cell cycle control |
| Ran | GTP-binding nuclear protein RAN, member RAS oncogene family | Cell cycle regulator |
| Mdm2 | Transformed mouse 3T3 cell double minute 2 | Cell growth and maintenance |
| Cct5 | Chaperonin subunit 5 ɛ | Chaperone |
| C1qa | Complement component 1, q subcomponent, α polypeptide | Complement component |
| Myo1c | Myosin Ic | Cytoskeleton organization and biogenesis |
| Ncl | Nucleolin | DNA, RNA binding |
| Madh5 | MAD homolog 5 | Embryogenesis and morphogenesis |
| Mt1 | Metallothionein1 | Heavy metal binding |
| Elavl3 | ELAV-like 3 (Hu antigen C) | Histogenesis and organogenesis |
| Igj | Immunoglobulin joining chain | Humoral defense mechanism |
| Ppia | Peptidylprolyl isomerase A | Immune response |
| Scya19 | Small inducible cytokine A19 | Inflammatory response |
| Itgb7 | Integrin β 7 | Integrin receptor signal signaling pathway |
| Emp3 | Epithelial membrane protein 3 | Membrane fraction |
| Vasp | Vasodilator-stimulated phosphoprotein | Mineralcorticoid metabolism |
| Ada | Adenosine deaminase | Nucleic acid metabolism |
| Ubb | Ubiquitin B | Nucleus |
| Gnas | Guanine nucleotide binding protein, α stimulating | Protein ADP-ribosylation |
| DHPS | Deoxyhypusine synthase | Protein biosynthesis |
| Eef1a1 | Elongation factor 1-alpha (EF 1-α) | Protein biosynthesis |
| Ptpn11 | Protein tyrosine phosphatase, nonreceptor type 11 | Protein tyrosine phosphatase |
| Impdh2 | IMP dehydrogenase | Purine nucleotide biosynthesis |
| Various | Ribosomal proteins L3, L4, L5, L6, L7, L10, L11, L13, L23a, L29 | Ribosome biogenesis |
| Various | Ribosomal proteins S3, S4, S6, S7, S12, S14, S16, S17, S19, S20 | Ribosome biogenesis |
| Fgfr4 | Fibroblast growth factor receptor 4 | Signal transduction |
| Nsp3 | SH2-containing protein 3 | Signal transduction |
| Rgl2 | Ral guanine nucleotide dissociation stimulator-like 2 | Signal transduction |
| Mint | Msx2-interacting nuclear target protein | Transcription factor |
| Mtf2 | Metal response element binding transcription factor 2 | Transcription factor |
| Bteb3 | Basic transcription element binding protein 3 | Transcription from Pol II promoter |
| Klf9 | Kruppel-like factor 9 | Transcription regulation |
| Creg | Cellular repressor of E1A-stimulated genes | Transcription regulation |
| Rb1 | Retinoblastoma 1 | Transcription regulation |
ELAV indicates embryonic lethal, abnormal vision; IMP, inosine 5′-monophosphate. Other abbreviations are explained in the Table 3footnote.