Table 1. The DNA enzyme inhibited... | American Society of Hematology

Table 1.

The DNA enzyme inhibited spontaneous JMML cell colony formation

Added compound	Colony numbers
Nil	94 ± 6
DOTAP	92 ± 8
Active DNA enzyme	33 ± 4^*
Inactive DNA enzyme	93 ± 8
GM-CSF	297 ± 34^†
TNF-α	185 ± 19^†
G-CSF	90 ± 8
Active DNA enzyme + GM-CSF	55 ± 6^*
Active DNA enzyme + TNF-α	63 ± 8^*
Active DNA enzyme + G-CSF	39 ± 6^*

Added compound	Colony numbers
Nil	94 ± 6
DOTAP	92 ± 8
Active DNA enzyme	33 ± 4^*
Inactive DNA enzyme	93 ± 8
GM-CSF	297 ± 34^†
TNF-α	185 ± 19^†
G-CSF	90 ± 8
Active DNA enzyme + GM-CSF	55 ± 6^*
Active DNA enzyme + TNF-α	63 ± 8^*
Active DNA enzyme + G-CSF	39 ± 6^*

Values are means ± SEM (n = 8) of the numbers of colonies per 75 000 plated JMML cells. The cytokines GM-CSF, TNF-α, and G-CSF were all added at concentrations of 10 ng/mL, whereas the DNA enzymes were added at concentrations of 1 μg/mL.

GM-CSF indicates granulocyte-macrophage colony-stimulating factor; TNF-α, tumor necrosis factor-α; G-CSF, granulocyte colony-stimulating factor.

Denotes a value significantly less than for the Nil group (P < .05).

†

Denotes a value significantly larger than for the Nil group (P < .05).

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