Serum glutamic-pyruvic transaminase levels in mice receiving first-generation adenovirus with different human factor IX expression cassettes 1 day after injection
| Injected transducing particles . | SGPT levels by virus, day 1 . | |||
|---|---|---|---|---|
| FgAdhFIXs, U/mL . | FgAdhFIXs ChMAR, U/mL . | FgAdhFIXs ChMAR IgκMAR, U/mL . | Negative control, U/mL . | |
| 1 × 109 | 7.6 ± 4.2 | 11.5 ± 2.7 | 35.8 ± 5 | 11.7 ± 4.8 |
| 1 × 108 | 6.8 ± 2.8 | 8.4 ± 3 | 17.0 ± 4.1 | – |
| 1 × 107 | 6.5 ± 2.4 | 16.6 ± 8.5 | 18.5 ± 5.1 | – |
| Injected transducing particles . | SGPT levels by virus, day 1 . | |||
|---|---|---|---|---|
| FgAdhFIXs, U/mL . | FgAdhFIXs ChMAR, U/mL . | FgAdhFIXs ChMAR IgκMAR, U/mL . | Negative control, U/mL . | |
| 1 × 109 | 7.6 ± 4.2 | 11.5 ± 2.7 | 35.8 ± 5 | 11.7 ± 4.8 |
| 1 × 108 | 6.8 ± 2.8 | 8.4 ± 3 | 17.0 ± 4.1 | – |
| 1 × 107 | 6.5 ± 2.4 | 16.6 ± 8.5 | 18.5 ± 5.1 | – |
Serum glutamic-pyruvic transaminase levels measure serum alanine aminotransferase activity; data are presented in international units.
SGPT indicates serum glutamic-pyruvic transaminase; fgAd, first-generation adenoviral vector; hFIX, human factor IX; ChMAR, chicken lysozyme matrix-attachment region.