Table 1. Patient characteristics . Total... | American Society of Hematology

Table 1.

Patient characteristics

	Total	Match	HLA mismatch locus^*			A/B+C	A/B+DR/DQ	C+DR/DQ	A/B+C+DR/DQ
	Total	Match	A/B	C	DR/DQ	A/B+C	A/B+DR/DQ	C+DR/DQ	A/B+C+DR/DQ
Number of cases	1298	566	118	156	141	124	45	90	58
Patient age (median, y)	23	23	25	22	24	25	24	24	21
Sex (Donor/patient)
Male/male	494	214	40	61	44	55	20	41	19
Male/female	268	112	30	32	28	22	10	22	12
Female/male	298	138	20	38	41	27	8	15	11
Female/female	238	102	28	25	28	20	7	12	16
Disease
AML	304	150	24	34	34	28	12	14	8
ALL	353	151	31	46	45	34	14	23	9
CML	367	141	39	42	39	36	15	29	26
MDS	99	43	12	15	8	9	1	7	4
Malignant lymphoma	39	23	1	3	6	0	0	3	3
Severe aplastic anemia	101	38	7	11	8	16	3	11	7
Hereditary disease	35	20	4	5	1	1	0	3	1
Risk of leukemia relapse
Standard	480	218	45	60	51	40	13	34	19
High	544	224	49	62	67	58	28	32	24
GVHD prophylaxis
Cyclosporine based	964	425	98	123	109	89	30	52	38
Tacrolimus based	141	65	9	14	18	10	5	13	7
ATG based	176	70	11	18	11	23	7	23	13
T-cell depletion	16	6	0	0	3	2	3	2	0
Preconditioning
TBI regimen	1027	447	99	121	109	98	34	73	46
Non-TBI regimen	271	119	19	35	32	26	11	17	12

	Total	Match	HLA mismatch locus^*			A/B+C	A/B+DR/DQ	C+DR/DQ	A/B+C+DR/DQ
	Total	Match	A/B	C	DR/DQ	A/B+C	A/B+DR/DQ	C+DR/DQ	A/B+C+DR/DQ
Number of cases	1298	566	118	156	141	124	45	90	58
Patient age (median, y)	23	23	25	22	24	25	24	24	21
Sex (Donor/patient)
Male/male	494	214	40	61	44	55	20	41	19
Male/female	268	112	30	32	28	22	10	22	12
Female/male	298	138	20	38	41	27	8	15	11
Female/female	238	102	28	25	28	20	7	12	16
Disease
AML	304	150	24	34	34	28	12	14	8
ALL	353	151	31	46	45	34	14	23	9
CML	367	141	39	42	39	36	15	29	26
MDS	99	43	12	15	8	9	1	7	4
Malignant lymphoma	39	23	1	3	6	0	0	3	3
Severe aplastic anemia	101	38	7	11	8	16	3	11	7
Hereditary disease	35	20	4	5	1	1	0	3	1
Risk of leukemia relapse
Standard	480	218	45	60	51	40	13	34	19
High	544	224	49	62	67	58	28	32	24
GVHD prophylaxis
Cyclosporine based	964	425	98	123	109	89	30	52	38
Tacrolimus based	141	65	9	14	18	10	5	13	7
ATG based	176	70	11	18	11	23	7	23	13
T-cell depletion	16	6	0	0	3	2	3	2	0
Preconditioning
TBI regimen	1027	447	99	121	109	98	34	73	46
Non-TBI regimen	271	119	19	35	32	26	11	17	12

AML indicates acute myelocytic leukemia; ALL, acute lymphoblastic leukemia; MDS, myelodysplastic syndrome; GVHD, graft-versus-host disease; ATG, antithymocyte globulin; TBI, total body irradiation.

Match: HLA-A, -B, -C, -DR, and -DQ allele match. A/B: HLA-A and/or HLA-B allele mismatch. C: HLA-C allele mismatch. DR/DQ: HLA-DRB1 and/or HLA-DQB1 mismatch in GVHD vector.

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