Table 3. Effect of HLA allele mismatch... | American Society of Hematology

Table 3.

Effect of HLA allele mismatch on acute graft-versus-host disease

HLA mismatch locus	No. of cases	Incidence of acute GVHD
HLA mismatch locus	No. of cases	Grade II-IV	P^3-150	Grade III-IV	P^3-150
Match	561	34.5	—	11.8	—
A/B	115	54.9	< .001	27.8	< .001
C	156	42.7	.030	20.6	.005
DR/DQ	141	34.4	.764	16.1	.139
A/B + C	123	60.9	< .001	37.0	< .001
A/B + DR/DQ	45	38.4	.391	18.3	.166
C + DR/DQ	90	55.7	< .001	30.9	< .001
A/B + C + DR/DQ	57	64.3	< .001	42.1	< .001

HLA mismatch locus	No. of cases	Incidence of acute GVHD
HLA mismatch locus	No. of cases	Grade II-IV	P^3-150	Grade III-IV	P^3-150
Match	561	34.5	—	11.8	—
A/B	115	54.9	< .001	27.8	< .001
C	156	42.7	.030	20.6	.005
DR/DQ	141	34.4	.764	16.1	.139
A/B + C	123	60.9	< .001	37.0	< .001
A/B + DR/DQ	45	38.4	.391	18.3	.166
C + DR/DQ	90	55.7	< .001	30.9	< .001
A/B + C + DR/DQ	57	64.3	< .001	42.1	< .001

P value compared with matched cases by univariate analyses.