Expression of chemokines in RS cell lines and primary cHL tissues
| Chemokine . | Biologic activity . | Expression by RS cell lines* . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| TARC | Th2 cell recruitment | 4/4 | 88 | |
| MDC | Th2 cell recruitment | ND | 87 | Higher in NSHL subtype |
| Eotaxin | Eosinophil, Th2 cell recruitment | 1/5 | 63 | Higher in NSHL subtype; associated with tissue eosinophilia |
| IP-10, Mig, MIP-1α | Th1 cell recruitment | ND | 100 | Higher in MCHL subtype and EBV+ cases |
| IL-8 | Neutrophil recruitment | ND | 61 | Associated with tissue neutrophilia |
| Chemokine . | Biologic activity . | Expression by RS cell lines* . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| TARC | Th2 cell recruitment | 4/4 | 88 | |
| MDC | Th2 cell recruitment | ND | 87 | Higher in NSHL subtype |
| Eotaxin | Eosinophil, Th2 cell recruitment | 1/5 | 63 | Higher in NSHL subtype; associated with tissue eosinophilia |
| IP-10, Mig, MIP-1α | Th1 cell recruitment | ND | 100 | Higher in MCHL subtype and EBV+ cases |
| IL-8 | Neutrophil recruitment | ND | 61 | Associated with tissue neutrophilia |
ND indicates not done.
Expression of cytokines in RS cell lines L-428, KM-H2, HDLM-2, L-1236, L-591, L-540, Co, Ho.