Expression of TNF ligand family members in RS cell lines and primary cHL tissues
| TNF ligand family member . | Biologic activity . | Expression by RS cell lines3-150 . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| TNF-α | Proinflammatory cytokine | 7/7 | 69 | |
| LT-α | Proinflammatory cytokine | 5/6 | 77 | |
| CD40L | B-cell/T-cell cooperation in humoral immune response | 0/4 | 100 | Expressed by reactive T-cells adjacent to CD40+ RS cells |
| CD30L | T-cell stimulation | 0/3 | 100 | Expressed by eosinophils, mast cells adjacent to CD30+ RS cells |
| RANKL | T-cell/dendritic cell interactions | 2/2 | 100 | Expressed by RANK+ RS cells |
| TNF ligand family member . | Biologic activity . | Expression by RS cell lines3-150 . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| TNF-α | Proinflammatory cytokine | 7/7 | 69 | |
| LT-α | Proinflammatory cytokine | 5/6 | 77 | |
| CD40L | B-cell/T-cell cooperation in humoral immune response | 0/4 | 100 | Expressed by reactive T-cells adjacent to CD40+ RS cells |
| CD30L | T-cell stimulation | 0/3 | 100 | Expressed by eosinophils, mast cells adjacent to CD30+ RS cells |
| RANKL | T-cell/dendritic cell interactions | 2/2 | 100 | Expressed by RANK+ RS cells |
Expression of cytokines in RS cell lines L-428, KM-H2, HDLM-2, L-1236, L-591, L-540, Co, Ho.