Expression of other cytokines in RS cell lines and primary cHL tissues
| Cytokine . | Biologic activity . | Expression by RS cell lines4-150 . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| IL-1 | Proinflammatory cytokine | 3/6 | 58 | |
| TGF-β | B- and T-cell suppression; fibroblast proliferation and collagen synthesis | 1/1 | 61 | Associated with NSHL subtype |
| IL-3 | Multilineage hematopoietic growth factor | 0/6 | 25 | |
| IL-7 | Precursor B- and T-cell growth factor | ND | 77 | |
| GM-CSF | Granulocytic and monocytic differentiation factor | 2/6 | 0 | |
| M-CSF | Monocytic growth and differentiation factor | 1/1 | 88 |
| Cytokine . | Biologic activity . | Expression by RS cell lines4-150 . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| IL-1 | Proinflammatory cytokine | 3/6 | 58 | |
| TGF-β | B- and T-cell suppression; fibroblast proliferation and collagen synthesis | 1/1 | 61 | Associated with NSHL subtype |
| IL-3 | Multilineage hematopoietic growth factor | 0/6 | 25 | |
| IL-7 | Precursor B- and T-cell growth factor | ND | 77 | |
| GM-CSF | Granulocytic and monocytic differentiation factor | 2/6 | 0 | |
| M-CSF | Monocytic growth and differentiation factor | 1/1 | 88 |
ND indicates not done.
Expression of cytokines in RS cell lines L-428, KM-H2, HDLM-2, L-1236, L-591, L-540, Co, Ho.