Comparison of cytogenetic aberrations and FLT3 mutations in patients with AML (n = 979)
| Karyotype characteristics . | ITD neg/TKD wt N (%) . | ITD pos N (%) . | TKD mut N (%) . | ITD pos + TKD mut N (%) . |
|---|---|---|---|---|
| All patients | 721 (73.6) | 183 (18.7) | 58 (5.9) | 17 (1.7) |
| Karyotype not available | 59 (8.2) | 22 (12.0) | 2 (3.4) | 0 (0) |
| Normal (XX,XY) | 282 (39.1) | 119 (65.0)‡ | 35 (60.3)2-153 | 15 (88.2)‡ |
| Aberrant | 380 (52.7) | 42 (23.0) | 21 (36.2) | 2 (11.8) |
| Individual aberrations | ||||
| t(8;21) | 38 (5.3) | 2 (1.1) | 1 (1.7) | 0 (0) |
| t(15;17) | 26 (3.6) | 13 (7.1)‡ | 4 (6.9) | 0 (0) |
| inv(16);t(16;16) | 36 (5) | 1 (0.6) | 5 (8.6) | 1 (4.8) |
| t(6;9)* | 1 (0.1) | 9 (4.9)‡ | 0 (0) | 0 (0) |
| t(3;3), inv(3q) | 10 (1.4) | 1 (0.6) | 0 (0) | 0 (0) |
| +8 | 69 (9.6) | 6 (3.3) | 6 (10.3) | 0 (0) |
| t(9;11);t(9;22) | 14 (1.9) | 0 (0) | 0 (0) | 0 (0) |
| +11/+13/+21/+22 | 75 (10.4) | 1 (0.6)2-153 | 4 (6.9) | 1 (4.8) |
| −5/5q− | 75 (10.4) | 2 (1.1)2-155 | 0 (0)2-155 | 0 (0) |
| −7/7q− | 86 (11.9) | 0 (0)‡ | 5 (8.6) | 0 (0) |
| Other monosomies | 94 (13.3) | 3 (1.6)2-155 | 1 (1.7)2-155 | 0 (0) |
| Multiple aberrations | 132 (18.3) | 3 (1.6)‡ | 5 (8.6) | 1 (4.8) |
| Karyotype characteristics . | ITD neg/TKD wt N (%) . | ITD pos N (%) . | TKD mut N (%) . | ITD pos + TKD mut N (%) . |
|---|---|---|---|---|
| All patients | 721 (73.6) | 183 (18.7) | 58 (5.9) | 17 (1.7) |
| Karyotype not available | 59 (8.2) | 22 (12.0) | 2 (3.4) | 0 (0) |
| Normal (XX,XY) | 282 (39.1) | 119 (65.0)‡ | 35 (60.3)2-153 | 15 (88.2)‡ |
| Aberrant | 380 (52.7) | 42 (23.0) | 21 (36.2) | 2 (11.8) |
| Individual aberrations | ||||
| t(8;21) | 38 (5.3) | 2 (1.1) | 1 (1.7) | 0 (0) |
| t(15;17) | 26 (3.6) | 13 (7.1)‡ | 4 (6.9) | 0 (0) |
| inv(16);t(16;16) | 36 (5) | 1 (0.6) | 5 (8.6) | 1 (4.8) |
| t(6;9)* | 1 (0.1) | 9 (4.9)‡ | 0 (0) | 0 (0) |
| t(3;3), inv(3q) | 10 (1.4) | 1 (0.6) | 0 (0) | 0 (0) |
| +8 | 69 (9.6) | 6 (3.3) | 6 (10.3) | 0 (0) |
| t(9;11);t(9;22) | 14 (1.9) | 0 (0) | 0 (0) | 0 (0) |
| +11/+13/+21/+22 | 75 (10.4) | 1 (0.6)2-153 | 4 (6.9) | 1 (4.8) |
| −5/5q− | 75 (10.4) | 2 (1.1)2-155 | 0 (0)2-155 | 0 (0) |
| −7/7q− | 86 (11.9) | 0 (0)‡ | 5 (8.6) | 0 (0) |
| Other monosomies | 94 (13.3) | 3 (1.6)2-155 | 1 (1.7)2-155 | 0 (0) |
| Multiple aberrations | 132 (18.3) | 3 (1.6)‡ | 5 (8.6) | 1 (4.8) |
Note that the number of patients with individual aberrations adds to a higher number than the absolute number of patients with aberrations because several patients had more than one aberration.
P values were calculated using Fisher exact test. For individual cytogenetic aberrations, the groups were compared with other patients with abnormal karyotypes.
Patients had t(6;9) as the sole abnormality (n = 9); one patient with a FLT3-ITD had t(13;13)(q11;q11).
Three or more structural or numerical chromosomal aberrations.
P < .001;
P< .01;
P < .05.