Table 6.

Induction outcome as a function of treatment presence or absence of DiOC2(3) efflux modulated by PSC-833 in vitro in patients with pretreatment samples studied for MDR

Efflux positive
(n = 43)
Efflux negative
(n = 23)
Total
(n = 66)
P
ADE     
 CR 9  (41%) 10  (91%) 19  (58%) .03 
 NR 9  (41%) 1  (9%) 10  (30%)  
 Death 4  (18%) 0  (0%) 4  (12%)  
 Total 22 11 33  
ADEP     
 CR 10  (48%) 6  (50%) 16  (48%) 1.0  
 NR 4  (19%) 2  (17%) 6  (18%)  
 Death 7  (33%) 4  (33%) 11  (33%)  
 Total 21 12 33  
Efflux positive
(n = 43)
Efflux negative
(n = 23)
Total
(n = 66)
P
ADE     
 CR 9  (41%) 10  (91%) 19  (58%) .03 
 NR 9  (41%) 1  (9%) 10  (30%)  
 Death 4  (18%) 0  (0%) 4  (12%)  
 Total 22 11 33  
ADEP     
 CR 10  (48%) 6  (50%) 16  (48%) 1.0  
 NR 4  (19%) 2  (17%) 6  (18%)  
 Death 7  (33%) 4  (33%) 11  (33%)  
 Total 21 12 33  

NR indicates alive, with no response.

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