Causes of death for patients with and without cGVHD
| . | No chronic GVHD (523 patients) . | Chronic GVHD (173 patients) . | Total (696 patients) . |
|---|---|---|---|
| Disease progression (%) | 88 (60) | 14 (31) | 102 (53) |
| Transplant-related causes (%) | 58 (40) | 31 (69) | 89 (47) |
| Bacterial pneumonia | 5 | 3 | |
| HCMV interstitial pneumonia | 2 | 0 | |
| Bacterial infection | 10 | 5 | |
| Fungal infection | 4 | 4 | |
| Viral infection | 0 | 1 | |
| EBV-PTLD | 2 | 0 | |
| Encephalitis | 2 | 0 | |
| ARDS | 5 | 1 | |
| Idiopathic interstitial pneumonia | 5 | 1 | |
| Autoimmune hemolytic anemia | 2 | 0 | |
| Thrombotic thrombocytopenic purpura | 2 | 0 | |
| Liver failure | 2 | 0 | |
| Renal failure | 0 | 1 | |
| Cardiac insufficiency | 1 | 0 | |
| Multiorgan failure | 6 | 2 | |
| Hemorrhage | 10 | 2 | |
| cGVHD | 0 | 11 | |
| Total | 146 | 45 | 191 |
| . | No chronic GVHD (523 patients) . | Chronic GVHD (173 patients) . | Total (696 patients) . |
|---|---|---|---|
| Disease progression (%) | 88 (60) | 14 (31) | 102 (53) |
| Transplant-related causes (%) | 58 (40) | 31 (69) | 89 (47) |
| Bacterial pneumonia | 5 | 3 | |
| HCMV interstitial pneumonia | 2 | 0 | |
| Bacterial infection | 10 | 5 | |
| Fungal infection | 4 | 4 | |
| Viral infection | 0 | 1 | |
| EBV-PTLD | 2 | 0 | |
| Encephalitis | 2 | 0 | |
| ARDS | 5 | 1 | |
| Idiopathic interstitial pneumonia | 5 | 1 | |
| Autoimmune hemolytic anemia | 2 | 0 | |
| Thrombotic thrombocytopenic purpura | 2 | 0 | |
| Liver failure | 2 | 0 | |
| Renal failure | 0 | 1 | |
| Cardiac insufficiency | 1 | 0 | |
| Multiorgan failure | 6 | 2 | |
| Hemorrhage | 10 | 2 | |
| cGVHD | 0 | 11 | |
| Total | 146 | 45 | 191 |
χ2 = 11.76, P = .0006 for the comparison of causes of death (disease progression versus transplant-related cause) in subjects with and without cGVHD.
For the 11 patients with cGVHD reported as the main cause of death, the ultimate cause of death was bronchiolitis obliterans in 4 cases, HCMV interstitial pneumonia in 1 case, bacterial pneumonia in 1 case, other bacterial infections in 3 cases, hemorrhagic complications in 1 case, and multiorgan failure in 1 case. HCMV indicates human cytomegalovirus; EBV-PTLD, Epstein-Barr virus–related posttransplantation lymphoproliferative disease; ARDS, acute respiratory distress syndrome.