Demographics of patients randomized to MP alone or LDMTX plus MP or HDMTX plus MP
| Demographic . | MP alone (n = 76) . | LDMTX plus MP (n = 83) . | HDMTX plus MP (n = 74) . | Intergroup comparison, P . |
|---|---|---|---|---|
| Age, y (range) | 5.9 | 5.9 | 5.9 | .74 |
| (0.1-18.6) | (0.5-17.1) | (0.3-18.8) | ||
| WBC day 0, × 109/L (range) | 6.3 | 7.5 | 7.4 | .83 |
| (1-225) | (1-399) | (1-276) | ||
| Sex | ||||
| Male | 42 | 52 | 40 | .49 |
| Female | 34 | 31 | 34 | |
| Immunophenotype | ||||
| T lineage | 14 | 13 | 11 | |
| B lineage | 61 | 70 | 62 | .82 |
| Nonhyperdiploid | 38 | 44 | 43 | |
| Hyperdiploid | 23 | 26 | 19 | |
| Unknown | 1 | 0 | 1 | |
| No. of patients with uricolytics administered within 72 h prior to bone marrow diagnosis | ||||
| Urate oxidase | 1 | 1 | 1 | .22 |
| Allopurinol alone or with urate oxidase | 8 | 2 | 6 | |
| None | 67 | 80 | 67 | |
| No. of patients with uricolytics administered within 72 h of posttreatment bone marrow sample | ||||
| Urate oxidase | 45 | 52 | 37 | .44 |
| Allopurinol alone or with urate oxidase | 5 | 5 | 9 | |
| None | 26 | 26 | 28 |
| Demographic . | MP alone (n = 76) . | LDMTX plus MP (n = 83) . | HDMTX plus MP (n = 74) . | Intergroup comparison, P . |
|---|---|---|---|---|
| Age, y (range) | 5.9 | 5.9 | 5.9 | .74 |
| (0.1-18.6) | (0.5-17.1) | (0.3-18.8) | ||
| WBC day 0, × 109/L (range) | 6.3 | 7.5 | 7.4 | .83 |
| (1-225) | (1-399) | (1-276) | ||
| Sex | ||||
| Male | 42 | 52 | 40 | .49 |
| Female | 34 | 31 | 34 | |
| Immunophenotype | ||||
| T lineage | 14 | 13 | 11 | |
| B lineage | 61 | 70 | 62 | .82 |
| Nonhyperdiploid | 38 | 44 | 43 | |
| Hyperdiploid | 23 | 26 | 19 | |
| Unknown | 1 | 0 | 1 | |
| No. of patients with uricolytics administered within 72 h prior to bone marrow diagnosis | ||||
| Urate oxidase | 1 | 1 | 1 | .22 |
| Allopurinol alone or with urate oxidase | 8 | 2 | 6 | |
| None | 67 | 80 | 67 | |
| No. of patients with uricolytics administered within 72 h of posttreatment bone marrow sample | ||||
| Urate oxidase | 45 | 52 | 37 | .44 |
| Allopurinol alone or with urate oxidase | 5 | 5 | 9 | |
| None | 26 | 26 | 28 |
All results are median (range) for quantitative variables.
WBC indicates white blood count.