Analysis of WM tumor–derived VH genes
| Patient . | VH family . | Germline gene . | Homology, % . | R/S mutation . | JH . | Tumor-derived clones/clones screened . | Tumor clones sequenced . | |
|---|---|---|---|---|---|---|---|---|
| FR . | CDR . | |||||||
| WM1 | VH 1 | V1-02 | 92.8 | 6/9 (0.7) | 6/0 (—) | JH4b | 7/10 | 7 |
| WM2 | VH 3 | V3-30 | 91.0 | 9/3 (3.0) | 9/5 (1.8) | JH 4b | 6/8 | 6 |
| WM3 | VH 3 | V3-53 | 95.5 | 5/3 (1.7) | 4/1 (4.0) | JH 6c | 8/10 | 6 |
| WM4 | VH 3 | V3-9 | 93.9 | 5/1 (5.0) | 8/4 (2.0) | JH 6b | 9/9 | 9 |
| WM5 | VH 3 | V3-23 | 89.4 | 7/7 (1.0) | 12/3 (4.0) | JH 6b | 17/18 | 16 |
| WM6 | VH 3 | V3-72 | 88.4 | 10/8 (1.3) | 9/4 (2.3) | JH 3b | 11/11 | 11 |
| WM7 | VH 1 | V1-02 | 93.2 | 12/4 (3.0) | 4/0 (—) | JH 4b | 8/24 | 8 |
| Patient . | VH family . | Germline gene . | Homology, % . | R/S mutation . | JH . | Tumor-derived clones/clones screened . | Tumor clones sequenced . | |
|---|---|---|---|---|---|---|---|---|
| FR . | CDR . | |||||||
| WM1 | VH 1 | V1-02 | 92.8 | 6/9 (0.7) | 6/0 (—) | JH4b | 7/10 | 7 |
| WM2 | VH 3 | V3-30 | 91.0 | 9/3 (3.0) | 9/5 (1.8) | JH 4b | 6/8 | 6 |
| WM3 | VH 3 | V3-53 | 95.5 | 5/3 (1.7) | 4/1 (4.0) | JH 6c | 8/10 | 6 |
| WM4 | VH 3 | V3-9 | 93.9 | 5/1 (5.0) | 8/4 (2.0) | JH 6b | 9/9 | 9 |
| WM5 | VH 3 | V3-23 | 89.4 | 7/7 (1.0) | 12/3 (4.0) | JH 6b | 17/18 | 16 |
| WM6 | VH 3 | V3-72 | 88.4 | 10/8 (1.3) | 9/4 (2.3) | JH 3b | 11/11 | 11 |
| WM7 | VH 1 | V1-02 | 93.2 | 12/4 (3.0) | 4/0 (—) | JH 4b | 8/24 | 8 |