Patients with definitive evidence of an IgH translocation in MGUS
| No. . | Translocation . | VH/CHsegregation assay (abnormal cells), % . | Fusion assay (abnormal cells), % . | Cyclin D1 . | Δ13 assay . | Heavy chain . | Light chain . | BM PCs, % . | Follow-up since diagnosis, mo . | Follow-up since translocation detection, mo . | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| deleted/ normal . | % . | ||||||||||
| 1 | t(11;14) | 89 | 100 | Negative | − | 6 | G | λ | 4.0 | 14.6 | 0.2 |
| 2 | t(11;14) | 90 | 100 | Positive | + | 87 | G | κ | 9.0 | 54.7 | 6.4 |
| 3 | t(11;14) | ND | 100 | Positive | ND | ND | G | κ | 12.0 | 10.0 | 7.4 |
| 4 | t(11;14) | 97 | 96 | Positive | − | 3 | None | κ | 3.0 | 2.0 | 0.1 |
| 5 | t(11;14) | 56 | 80 | Positive | − | 0 | G | λ | 5.0 | 42.7 | 42.7 |
| 6 | t(11;14) | 50 | 76 | Positive | + | 10 | G | λ | 1.0 | 50.5 | 50.5 |
| 7 | t(11;14) | 54 | 69 | Positive | + | 100 | G | λ | 8.0 | 13.6 | 0.0 |
| 8 | t(11;14) | ND | 64 | Positive | ND | ND | None | κ | 9.0 | 22.9 | 1183.0 |
| 9 | t(11;14) | 55 | 62 | Negative | + | 100 | G | κ | 2.0 | 0.1 | 0.0 |
| 10 | t(11;14) | 72 | 57 | Positive | ND | ND | G | λ | 5.0 | 52.8 | 52.8 |
| 11 | t(11;14) | 61 | 54 | Negative | − | 5 | G | κ | 2.0 | 5.8 | 5.8 |
| 12 | t(11;14) | 57 | 52 | Negative | + | 48 | G | κ | 7.0 | 38.4 | 2.8 |
| 13 | t(11;14) | 27 | 39 | Negative | + | 91 | G | κ | 2.0 | 21.0 | 21.0 |
| 14 | t(11;14) | 18 | 25 | Negative | − | 6 | G | λ | 8.0 | 9.5 | 8.9 |
| (IgL-λ) | 25 | ||||||||||
| 15 | t(11;14) | 100 | 30 | Negative | + | 91 | G | λ | 4.0 | 50.3 | 7.0 |
| t(4;14) | 91 | ||||||||||
| 16 | t(4;14) | 79 | 86 | ND | ND | ND | G | κ | 7.0 | 35.5 | 14.2 |
| 17 | t(4;14) | 49 | 66 | ND | + | 98 | G | λ | 5.0 | 20.6 | 8.7 |
| 18 | t(4;14) | 37 | 34 | ND | − | 8 | G | λ | 4.0 | 53.2 | 11.9 |
| 19 | t(4;14) | 98 | 100 | Negative | + | 99 | G | λ | 33.0 | 58.0 | 6.5 |
| t(14;16) | 100 | ||||||||||
| 20 | t(14;16) | 50 | 50 | ND | ND | ND | G | λ | 2.0 | 66.4 | 25.1 |
| 21 | t(14;16) | 42 | 25 | ND | ND | ND | G | λ | 3.0 | 24.2 | 24.5 |
| 22 | 14q32+ | 94 | NA | Negative | + | 100 | G | κ | 5.0 | 6.4 | 6.4 |
| 23 | 14q32+ | 28 | NA | ND | − | 0 | G | λ | 0.2 | 6.2 | 6.1 |
| 24 | 14q32+ | 47 | NA | ND | ND | ND | G | λ | 0.0 | 15.8 | 15.8 |
| 25 | 14q32+ | 26 | NA | ND | + | 16 | G | κ | TFTC | 3.2 | 0.0 |
| 26 | 14q32+ | 32 | NA | ND | ND | ND | G | κ | 1.9 | 30.4 | 15.6 |
| 27 | 14q32+ | 30 | NA | ND | ND | ND | G | λ | 5.0 | 12.0 | 12.0 |
| No. . | Translocation . | VH/CHsegregation assay (abnormal cells), % . | Fusion assay (abnormal cells), % . | Cyclin D1 . | Δ13 assay . | Heavy chain . | Light chain . | BM PCs, % . | Follow-up since diagnosis, mo . | Follow-up since translocation detection, mo . | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| deleted/ normal . | % . | ||||||||||
| 1 | t(11;14) | 89 | 100 | Negative | − | 6 | G | λ | 4.0 | 14.6 | 0.2 |
| 2 | t(11;14) | 90 | 100 | Positive | + | 87 | G | κ | 9.0 | 54.7 | 6.4 |
| 3 | t(11;14) | ND | 100 | Positive | ND | ND | G | κ | 12.0 | 10.0 | 7.4 |
| 4 | t(11;14) | 97 | 96 | Positive | − | 3 | None | κ | 3.0 | 2.0 | 0.1 |
| 5 | t(11;14) | 56 | 80 | Positive | − | 0 | G | λ | 5.0 | 42.7 | 42.7 |
| 6 | t(11;14) | 50 | 76 | Positive | + | 10 | G | λ | 1.0 | 50.5 | 50.5 |
| 7 | t(11;14) | 54 | 69 | Positive | + | 100 | G | λ | 8.0 | 13.6 | 0.0 |
| 8 | t(11;14) | ND | 64 | Positive | ND | ND | None | κ | 9.0 | 22.9 | 1183.0 |
| 9 | t(11;14) | 55 | 62 | Negative | + | 100 | G | κ | 2.0 | 0.1 | 0.0 |
| 10 | t(11;14) | 72 | 57 | Positive | ND | ND | G | λ | 5.0 | 52.8 | 52.8 |
| 11 | t(11;14) | 61 | 54 | Negative | − | 5 | G | κ | 2.0 | 5.8 | 5.8 |
| 12 | t(11;14) | 57 | 52 | Negative | + | 48 | G | κ | 7.0 | 38.4 | 2.8 |
| 13 | t(11;14) | 27 | 39 | Negative | + | 91 | G | κ | 2.0 | 21.0 | 21.0 |
| 14 | t(11;14) | 18 | 25 | Negative | − | 6 | G | λ | 8.0 | 9.5 | 8.9 |
| (IgL-λ) | 25 | ||||||||||
| 15 | t(11;14) | 100 | 30 | Negative | + | 91 | G | λ | 4.0 | 50.3 | 7.0 |
| t(4;14) | 91 | ||||||||||
| 16 | t(4;14) | 79 | 86 | ND | ND | ND | G | κ | 7.0 | 35.5 | 14.2 |
| 17 | t(4;14) | 49 | 66 | ND | + | 98 | G | λ | 5.0 | 20.6 | 8.7 |
| 18 | t(4;14) | 37 | 34 | ND | − | 8 | G | λ | 4.0 | 53.2 | 11.9 |
| 19 | t(4;14) | 98 | 100 | Negative | + | 99 | G | λ | 33.0 | 58.0 | 6.5 |
| t(14;16) | 100 | ||||||||||
| 20 | t(14;16) | 50 | 50 | ND | ND | ND | G | λ | 2.0 | 66.4 | 25.1 |
| 21 | t(14;16) | 42 | 25 | ND | ND | ND | G | λ | 3.0 | 24.2 | 24.5 |
| 22 | 14q32+ | 94 | NA | Negative | + | 100 | G | κ | 5.0 | 6.4 | 6.4 |
| 23 | 14q32+ | 28 | NA | ND | − | 0 | G | λ | 0.2 | 6.2 | 6.1 |
| 24 | 14q32+ | 47 | NA | ND | ND | ND | G | λ | 0.0 | 15.8 | 15.8 |
| 25 | 14q32+ | 26 | NA | ND | + | 16 | G | κ | TFTC | 3.2 | 0.0 |
| 26 | 14q32+ | 32 | NA | ND | ND | ND | G | κ | 1.9 | 30.4 | 15.6 |
| 27 | 14q32+ | 30 | NA | ND | ND | ND | G | λ | 5.0 | 12.0 | 12.0 |
− indicates normal; +, deleted; ND, not done; TFTC, too few cells to count.