Treatment of nude athymic rats with antigranulocyte and antimacrophage antibodies allows some T9-C2 tumors to grow
| Treatment . | No. with tumors/total no. of rats injected (% with tumors) . |
|---|---|
| Normal rabbit serum | 0/6 (0) |
| Anti-NK antibody | 0/5 (0) |
| Anti-PMN antibody | 2/5 (40)* |
| Antimacrophage antibody | 2/5 (40)* |
| Anti-PMN and antimacrophage | 4/5 (80)† |
| Treatment . | No. with tumors/total no. of rats injected (% with tumors) . |
|---|---|
| Normal rabbit serum | 0/6 (0) |
| Anti-NK antibody | 0/5 (0) |
| Anti-PMN antibody | 2/5 (40)* |
| Antimacrophage antibody | 2/5 (40)* |
| Anti-PMN and antimacrophage | 4/5 (80)† |
The rats were injected 5 times over a 10-day period. Two injections occurred following subcutaneous injection of 105T9-C2 cells. After 30 days, the presence or absence of T9-C2 tumors was noted.
The result was not significantly different (by Fisher exact test) from the results for rats injected with normal rabbit serum (P = .182).
The result was significantly different (by Fisher exact test) from the results for rats injected with normal rabbit serum (P = .015) or anti-NK antibody (P = .048).