Distribution of IgVH and JH gene families in unmutated (UM) and mutated (MUT) mantle cell lymphoma (MCL)
. | UM normal B cells CD5+IgM+,* n = 113 (%) . | MUT normal B cells CD5+IgM+,* n = 31 (%) . | UM MCL, n = 40 (%) . | MUT MCL, n = 22 (%) . |
|---|---|---|---|---|
| VH family | ||||
| VH 1 | 24 (21.2) | 3 (9.7) | 9 (22.5) | 4 (18.2) |
| VH 2 | 2 (1.8) | 1 (3.2) | 0 | 0 |
| VH 3 | 59 (52.2) | 22 (71.0) | 19 (47.5) | 13 (59.1) |
| VH 4 | 21 (18.6) | 5 (16.1) | 8 (20.0) | 4 (18.2) |
| VH 5 | 2 (1.8) | 0 | 3 (7.5) | 0 |
| VH 6 | 2 (1.8) | 0 | 1 (2.5) | 1 (4.6) |
| VH 7 | 3 (2.7) | 0 | 0 | 0 |
| JH family | ||||
| JH1 | 0 | 1 (3.2) | 0 | 0 |
| JH2 | 4 (3.5) | 1 (3.2) | 1 (2.5) | 0 |
| JH3 | 4 (3.5) | 5 (16.1) | 5 (12.5) | 2 (9.1) |
| JH4 | 54 (47.8) | 21 (67.7) | 21 (52.5) | 11 (50.0) |
| JH5 | 13 (11.5) | 2 (6.5) | 9 (22.5) | 7 (31.8) |
| JH6 | 38 (33.6) | 1 (3.2) | 4 (10.0) | 2 (9.1) |
. | UM normal B cells CD5+IgM+,* n = 113 (%) . | MUT normal B cells CD5+IgM+,* n = 31 (%) . | UM MCL, n = 40 (%) . | MUT MCL, n = 22 (%) . |
|---|---|---|---|---|
| VH family | ||||
| VH 1 | 24 (21.2) | 3 (9.7) | 9 (22.5) | 4 (18.2) |
| VH 2 | 2 (1.8) | 1 (3.2) | 0 | 0 |
| VH 3 | 59 (52.2) | 22 (71.0) | 19 (47.5) | 13 (59.1) |
| VH 4 | 21 (18.6) | 5 (16.1) | 8 (20.0) | 4 (18.2) |
| VH 5 | 2 (1.8) | 0 | 3 (7.5) | 0 |
| VH 6 | 2 (1.8) | 0 | 1 (2.5) | 1 (4.6) |
| VH 7 | 3 (2.7) | 0 | 0 | 0 |
| JH family | ||||
| JH1 | 0 | 1 (3.2) | 0 | 0 |
| JH2 | 4 (3.5) | 1 (3.2) | 1 (2.5) | 0 |
| JH3 | 4 (3.5) | 5 (16.1) | 5 (12.5) | 2 (9.1) |
| JH4 | 54 (47.8) | 21 (67.7) | 21 (52.5) | 11 (50.0) |
| JH5 | 13 (11.5) | 2 (6.5) | 9 (22.5) | 7 (31.8) |
| JH6 | 38 (33.6) | 1 (3.2) | 4 (10.0) | 2 (9.1) |