Comparison of clinical characteristics of patients who achieve low MRD status (< 0.05% LAP+ cells) to those who did not achieve this level (high MRD: ≥ 0.05%) at day +35
. | Cases with MRD level < 0.05% at day +35 . | Cases with MRD level at least 0.05% at day +35 . | P . |
|---|---|---|---|
| Sex, male/female | 23/20 | 40/19 | .14 |
| Age, in years (range)* | 23 (15-74) | 35 (15-82) | .03 |
| WBC count, ×109/L* (range) | 11.9 (0.3-857) | 10.6 (0.9-295) | .93 |
| Hb level, g/dL* (range) | 9.5 (4.5-15) | 11.4 (4.8-19) | .24 |
| Platelets, ×106/L* (range) | 55 (3-224) | 54 (9-292) | .25 |
| Percent blast cells in PB* (range) | 59 (0-98) | 52 (0-100) | .74 |
| Percent blast cells in BM* (range) | 74 (30-98) | 80 (30-98) | .10 |
| Adverse karyotype: Ph′-positive, hypodiploid, complex (percent) | 5/29 (17%) | (12/46) (26%) | .06 |
| Inmmunophenotype | |||
| B-ALL (%) | 34 (79) | 39 (66) | .11 |
| T-ALL (%) | 9 (21) | 20 (34) | |
| Consolidation therapy | |||
| Chemotherapy (%) | 29 (66) | 36 (62) | .83 |
| Autologous BMT (%) | 5 (12) | 9 (16) | |
| Allogeneic BMT (%) | 10 (23) | 13 (22) |
. | Cases with MRD level < 0.05% at day +35 . | Cases with MRD level at least 0.05% at day +35 . | P . |
|---|---|---|---|
| Sex, male/female | 23/20 | 40/19 | .14 |
| Age, in years (range)* | 23 (15-74) | 35 (15-82) | .03 |
| WBC count, ×109/L* (range) | 11.9 (0.3-857) | 10.6 (0.9-295) | .93 |
| Hb level, g/dL* (range) | 9.5 (4.5-15) | 11.4 (4.8-19) | .24 |
| Platelets, ×106/L* (range) | 55 (3-224) | 54 (9-292) | .25 |
| Percent blast cells in PB* (range) | 59 (0-98) | 52 (0-100) | .74 |
| Percent blast cells in BM* (range) | 74 (30-98) | 80 (30-98) | .10 |
| Adverse karyotype: Ph′-positive, hypodiploid, complex (percent) | 5/29 (17%) | (12/46) (26%) | .06 |
| Inmmunophenotype | |||
| B-ALL (%) | 34 (79) | 39 (66) | .11 |
| T-ALL (%) | 9 (21) | 20 (34) | |
| Consolidation therapy | |||
| Chemotherapy (%) | 29 (66) | 36 (62) | .83 |
| Autologous BMT (%) | 5 (12) | 9 (16) | |
| Allogeneic BMT (%) | 10 (23) | 13 (22) |
Values represent means.