Comparison of CSF and plasma imatinib mesylate concentrations
. | Imatinib mesylate . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | Drug . | . | Metabolite . | . | |||
| Concentration . | ng/mL . | μM . | ng/mL . | μM . | |||
| Plasma, average | 6958 (± 2082) | 11.8 (± 3.5) | 611 (± 179) | 1.0 (± 0.3) | |||
| CSF, pooled | 45 | 0.08 | 0 | 0 | |||
| Plasma/CSF ratio | 154.6 | NA | |||||
. | Imatinib mesylate . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | Drug . | . | Metabolite . | . | |||
| Concentration . | ng/mL . | μM . | ng/mL . | μM . | |||
| Plasma, average | 6958 (± 2082) | 11.8 (± 3.5) | 611 (± 179) | 1.0 (± 0.3) | |||
| CSF, pooled | 45 | 0.08 | 0 | 0 | |||
| Plasma/CSF ratio | 154.6 | NA | |||||
Results depict the average plasma concentrations of imatinib mesylate and CGP 74588 (metabolite) and the pooled CSF values of a cohort of imatinib mesylate—treated mice (N = 9). The standard error for the imatinib mesylate plasma values is shown in parentheses. NA indicates not applicable.