Plasma levels of factor V and factor VII clotting activity and of PAI-1
. | Protein C+/- . | Protein C+/+ . | P . |
|---|---|---|---|
| Factor V, % | |||
| Baseline | 105 ± 7 | 101 ± 8 | .3 |
| 4 h | 52 ± 12 | 71 ± 9 | .04 |
| 12 h | 36 ± 9 | 53 ± 11 | .01 |
| Factor VII, % | |||
| Baseline | 98 ± 3 | 107 ± 4 | .6 |
| 4 h | 48 ± 7 | 56 ± 6 | .05 |
| 12 h | 27 ± 5 | 42 ± 5 | .005 |
| PAI-1, ng/mL | |||
| Baseline | 2.5 ± 1.1 | 2.8 ± 1.2 | .5 |
| 4 h | 7.5 ± 2.4 | 5.9 ± 2.9 | .09 |
| 12 h | 12.9 ± 2.7 | 10.1 ± 2.2 | .1 |
. | Protein C+/- . | Protein C+/+ . | P . |
|---|---|---|---|
| Factor V, % | |||
| Baseline | 105 ± 7 | 101 ± 8 | .3 |
| 4 h | 52 ± 12 | 71 ± 9 | .04 |
| 12 h | 36 ± 9 | 53 ± 11 | .01 |
| Factor VII, % | |||
| Baseline | 98 ± 3 | 107 ± 4 | .6 |
| 4 h | 48 ± 7 | 56 ± 6 | .05 |
| 12 h | 27 ± 5 | 42 ± 5 | .005 |
| PAI-1, ng/mL | |||
| Baseline | 2.5 ± 1.1 | 2.8 ± 1.2 | .5 |
| 4 h | 7.5 ± 2.4 | 5.9 ± 2.9 | .09 |
| 12 h | 12.9 ± 2.7 | 10.1 ± 2.2 | .1 |
Plasma levels of factor V and factor VII clotting activity and of PAI-1 before and after the administration of endotoxin to protein C+/- mice and wild-type littermates (protein C+/+) (n = 6 at each time point in both groups). Values are means ± SD.