Table 4. Myeloid and monocytic... | American Society of Hematology

Table 4.

Myeloid and monocytic dyspoiesis detected by flow cytometry

	Patient group
Flow cytometric abnormality	MDS (n = 115)	Aplastic anemia (n = 26)	Nonhematopoietic malignancies (n = 15)	Hodgkin disease (n = 26)	Bone marrow transplant donors with cytopenias (n = 37)	All non-MDS subjects (n = 104)
Abnormal myeloblasts, no. (%)	72 (62)	0 (0)^*	0 (0)^*	0 (0)^*	1 (3)^*	1 (1)^*
Maturing myeloid
Abnormal granularity	9 (8)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)^*
Abnormal decrease CD45	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal relationship CD13/CD16	27 (23)	3 (12)	0 (0)^*	3 (12)	6 (16)	12 (12)^*
Abnormal relationships
HLA-DR/CD11b	6 (5)	0 (0)	0 (0)	1 (4)	1 (3)	2 (2)
Asynchronous shift to the left	26 (23)	0 (0)^*	0 (0)^*	0 (0)^*	0 (0)^*	0 (0)^*
Presence of CD56	18 (16)	1 (4)	1 (7)	6 (23)	0 (0)^*	8 (8)
Lack of CD33	6 (5)	1 (4)	0 (0)	0 (0)	3 (8)	4 (4)
Presence of CD34	7 (6)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)^*
Presence of lymphoid antigens	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Monocytes
Abnormal granularity	1 (1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Lack of CD13 or CD16	1 (1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal relationship HLA-DR/CD11b	5 (4)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Presence of CD56	19 (17)	0 (0)^*	0 (0)	3 (12)	0 (0)^*	3 (3)^*
Lack of CD33 or CD14	3 (3)	0 (0)	0 (0)	0 (0)	0 (0)^*	0 (0)
Presence of CD34	14 (12)	0 (0)	0 (0)	0 (0)	0 (0)^*	0 (0)^*
Presence of lymphoid antigens	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal L/M ratio	38 (33)	19 (73)†	1 (7)^*	0 (0)^*	1 (3)^*	21 (20)^*
Abnormal cytogenetics	71 (62)‡	0 (0)^*	0 (0)^*	1 (4)^*	0 (0)^*	1 (1)^*

	Patient group
Flow cytometric abnormality	MDS (n = 115)	Aplastic anemia (n = 26)	Nonhematopoietic malignancies (n = 15)	Hodgkin disease (n = 26)	Bone marrow transplant donors with cytopenias (n = 37)	All non-MDS subjects (n = 104)
Abnormal myeloblasts, no. (%)	72 (62)	0 (0)^*	0 (0)^*	0 (0)^*	1 (3)^*	1 (1)^*
Maturing myeloid
Abnormal granularity	9 (8)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)^*
Abnormal decrease CD45	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal relationship CD13/CD16	27 (23)	3 (12)	0 (0)^*	3 (12)	6 (16)	12 (12)^*
Abnormal relationships
HLA-DR/CD11b	6 (5)	0 (0)	0 (0)	1 (4)	1 (3)	2 (2)
Asynchronous shift to the left	26 (23)	0 (0)^*	0 (0)^*	0 (0)^*	0 (0)^*	0 (0)^*
Presence of CD56	18 (16)	1 (4)	1 (7)	6 (23)	0 (0)^*	8 (8)
Lack of CD33	6 (5)	1 (4)	0 (0)	0 (0)	3 (8)	4 (4)
Presence of CD34	7 (6)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)^*
Presence of lymphoid antigens	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Monocytes
Abnormal granularity	1 (1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Lack of CD13 or CD16	1 (1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal relationship HLA-DR/CD11b	5 (4)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Presence of CD56	19 (17)	0 (0)^*	0 (0)	3 (12)	0 (0)^*	3 (3)^*
Lack of CD33 or CD14	3 (3)	0 (0)	0 (0)	0 (0)	0 (0)^*	0 (0)
Presence of CD34	14 (12)	0 (0)	0 (0)	0 (0)	0 (0)^*	0 (0)^*
Presence of lymphoid antigens	4 (3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Abnormal L/M ratio	38 (33)	19 (73)†	1 (7)^*	0 (0)^*	1 (3)^*	21 (20)^*
Abnormal cytogenetics	71 (62)‡	0 (0)^*	0 (0)^*	1 (4)^*	0 (0)^*	1 (1)^*

The data field shows the number with percentage in parentheses.

Number of abnormalities are significantly lower than MDS patients (P of a 2-sided Fisher exact test < .05).

Number of abnormalities is significantly higher than MDS patients (P of a 2-sided Fisher exact test < .05).

One patient missing cytogenetic data.