Table 3. Effect of oral deferiprone... | American Society of Hematology

Table 3.

Effect of oral deferiprone therapy on liver iron concentration in patients with thalassemia major

					Liver iron, mean or median mg/g dry weight
Study	Method of measurement	No. patients	Dose mg/kg per day	Duration, y	Initial	Final	Significance, P
Mazza et al³⁸	Biopsy	20	70	> 1	16.1	21.0	NS
Olivieri et al¹⁹	SQUID or Biopsy^*	21	75	3.1	80.7 μmol†	46.8 μmol†	< .005
Olivieri et al²⁰	SQUID or Biopsy^*	18	75	4.6	88.7 μmol†	65.5 μmol†	NS
Olivieri, Brittenham⁴³	SQUID or Biopsy	19	75	2.75	8.9	13.7	< .01
Del Vecchio et al³³	SQUID	9	75	1.5	16.9	3.0	NS
Maggio et al²¹	Biopsy	20	75	2.5	3.4	2.3	NS

					Liver iron, mean or median mg/g dry weight
Study	Method of measurement	No. patients	Dose mg/kg per day	Duration, y	Initial	Final	Significance, P
Mazza et al³⁸	Biopsy	20	70	> 1	16.1	21.0	NS
Olivieri et al¹⁹	SQUID or Biopsy^*	21	75	3.1	80.7 μmol†	46.8 μmol†	< .005
Olivieri et al²⁰	SQUID or Biopsy^*	18	75	4.6	88.7 μmol†	65.5 μmol†	NS
Olivieri, Brittenham⁴³	SQUID or Biopsy	19	75	2.75	8.9	13.7	< .01
Del Vecchio et al³³	SQUID	9	75	1.5	16.9	3.0	NS
Maggio et al²¹	Biopsy	20	75	2.5	3.4	2.3	NS

Some patients underwent initial liver biopsy by SQUID, subsequently by liver biopsy, and vice versa.

μmol/g wet weight.