Clinical and laboratory characteristics of the study cohort
Variable . | Hemoglobin SS, n = 41 . | Hemoglobin SC, Sβthal, n = 5 . | Hemoglobin AS, n = 7 . | Hemoglobin AA, n = 24 . |
|---|---|---|---|---|
| Median age, y | 22 ± 16 | 27 ± 14 | 37 ± 14 | 41 ± 19* |
| Sex, M/F | 23/18 | 1/4 | 2/5 | 14/10 |
| Number (%) receiving hydroxyurea treatment | 28 (68) | 1 (20) | 0 (0) | 0 (0) |
| Hemoglobin, g/dL | 9.0 ± 1.6* | 10.4 ± 2.7 | 12.4 ± 0.9† | 13.3 ± 1.2‡ |
| White blood cells, 103/μL | 11.7 ± 5.6* | 13.8 ± 5.0 | 6.5 ± 1.0§ | 5.9 ± 1.4‡ |
| Absolute neutrophils, 103/μL | 6.1 ± 3.9∥ | 8.6 ± 3.2 | 3.6 ± 1.2§ | 2.9 ± 0.9# |
| Absolute lymphocytes, 103/μL | 3.8 ± 1.9∥ | 4.3 ± 2.2 | 2.3 ± 0.9§ | 1.3 ± 1.3# |
| Absolute monocytes, 103/μL | 1.3 ± 1.6∥ | 0.8 ± 0.4 | 0.4 ± 0.1§ | 0.4 ± 0.1** |
| Platelets, 103/μL | 397 ± 143* | 392 ± 145 | 280 ± 98§ | 222 ± 61‡ |
| Plasma iron, μg/dL | 164 ± 90∥ | 162 ± 55§ | 139 ± 75 | 118 ± 66# |
| Ferritin, ng/mL in median (range) | 262†† (16-5523) | 413‡‡ (128-2224) | 30§§ (6-483) | 46∥∥ (10-1468) |
Variable . | Hemoglobin SS, n = 41 . | Hemoglobin SC, Sβthal, n = 5 . | Hemoglobin AS, n = 7 . | Hemoglobin AA, n = 24 . |
|---|---|---|---|---|
| Median age, y | 22 ± 16 | 27 ± 14 | 37 ± 14 | 41 ± 19* |
| Sex, M/F | 23/18 | 1/4 | 2/5 | 14/10 |
| Number (%) receiving hydroxyurea treatment | 28 (68) | 1 (20) | 0 (0) | 0 (0) |
| Hemoglobin, g/dL | 9.0 ± 1.6* | 10.4 ± 2.7 | 12.4 ± 0.9† | 13.3 ± 1.2‡ |
| White blood cells, 103/μL | 11.7 ± 5.6* | 13.8 ± 5.0 | 6.5 ± 1.0§ | 5.9 ± 1.4‡ |
| Absolute neutrophils, 103/μL | 6.1 ± 3.9∥ | 8.6 ± 3.2 | 3.6 ± 1.2§ | 2.9 ± 0.9# |
| Absolute lymphocytes, 103/μL | 3.8 ± 1.9∥ | 4.3 ± 2.2 | 2.3 ± 0.9§ | 1.3 ± 1.3# |
| Absolute monocytes, 103/μL | 1.3 ± 1.6∥ | 0.8 ± 0.4 | 0.4 ± 0.1§ | 0.4 ± 0.1** |
| Platelets, 103/μL | 397 ± 143* | 392 ± 145 | 280 ± 98§ | 222 ± 61‡ |
| Plasma iron, μg/dL | 164 ± 90∥ | 162 ± 55§ | 139 ± 75 | 118 ± 66# |
| Ferritin, ng/mL in median (range) | 262†† (16-5523) | 413‡‡ (128-2224) | 30§§ (6-483) | 46∥∥ (10-1468) |
Results are given as mean ± standard deviation unless otherwise stated. Conversion to Sl units for white blood cells, absolute neutrophils, absolute lymphocytes, absolute monocytes, and platelets: 103/μL × 1 = × 109/L; ferritin: ng/mL × 1 = μg/L.
n = 38.
n = 5.
n = 10.
n = 4.
n = 34.
n = 9.
n = 8.
n = 20.
n = 3.
n = 6.
n = 6.