BCR-ABL kinase domain mutations
Mutation . | Nucleotide substitution (GenBank no. M14752) . | No. of patients with the mutation* . |
|---|---|---|
| Met244Val | 730A>G | 1 |
| Leu248Val | 742C>G | 1 |
| Gly250Glu | 749G>A | 2 |
| Gln252His | 756G>C | 4 |
| Gln252His | 756G>T | 1 |
| Tyr253Phe | 758A>T | 2 |
| Glu255Lys | 763G>A | 5 |
| Glu255Val | 764A>T | 1 |
| Thr315lle | 944C>T | 2 |
| Phe317Leu | 951C>G | 2 |
| Met351Thr | 1052T>C | 8 |
| Glu355GLy | 1064A>G | 3 |
| Phe359Val | 1075T>G | 2 |
| His396Arg | 1187A>G | 1 |
| Ser417Tyr | 1250C>A | 1 |
| Glu459Lys | 1375G>A | 1 |
| Phe486Ser | 1457T>C | 1 |
Mutation . | Nucleotide substitution (GenBank no. M14752) . | No. of patients with the mutation* . |
|---|---|---|
| Met244Val | 730A>G | 1 |
| Leu248Val | 742C>G | 1 |
| Gly250Glu | 749G>A | 2 |
| Gln252His | 756G>C | 4 |
| Gln252His | 756G>T | 1 |
| Tyr253Phe | 758A>T | 2 |
| Glu255Lys | 763G>A | 5 |
| Glu255Val | 764A>T | 1 |
| Thr315lle | 944C>T | 2 |
| Phe317Leu | 951C>G | 2 |
| Met351Thr | 1052T>C | 8 |
| Glu355GLy | 1064A>G | 3 |
| Phe359Val | 1075T>G | 2 |
| His396Arg | 1187A>G | 1 |
| Ser417Tyr | 1250C>A | 1 |
| Glu459Lys | 1375G>A | 1 |
| Phe486Ser | 1457T>C | 1 |
Seven patients had multiple mutations.