Table 2. Effect of growth factor... | American Society of Hematology

Table 2.

Effect of growth factor administration on hematopoietic progenitor and lymphoid precursor cells in BM and spleen of NOD/SCID mice with transplanted CD34⁺ cord blood cells

	Bone marrow^*
		CD34⁺	CD34⁺	CD34⁺	CD34⁻		CD34⁺	CD34⁺	CD34⁻
Treatment (no. mice)	CD34⁺	CD19⁺	CD19⁻	CD7⁺	CD7⁺	CD34⁺	CD19⁻	CD7⁺	CD7⁺
No treatment (20)	19.0 ± 1.1	13.2 ± 1.2	4.9 ± 0.4	0.9 ± 0.1	0.8 ± 0.1	6.4 ± 0.9	2.7 ± 0.6	< 0.1	1.1 ± 0.2
IL-15/FL (7)	7.7 ± 1.8^*	2.1 ± 0.4^*	5.5 ± 1.8	1.3 ± 0.5	4.0 ± 1.1^*	7.3 ± 0.7	2.4 ± 0.4	< 0.1	5.3 ± 2.0^*
IL-15/FL/SCF (6)	9.7 ± 1.8†	2.7 ± 0.7^*	7.1 ± 1.4	1.1 ± 0.4	4.5 ± 1.3^*	5.5 ± 0.3	3.0 ± 0.5	< 0.1	4.5 ± 0.9^*
IL-15/FL/IL-12 (5)	8.3 ± 0.6†	4.2 ± 1.1^*	4.2 ± 0.5	0.7 ± 0.15	3.9 ± 1.3†	7.3 ± 2.4	1.5 ± 0.3	0.15 ± 0.02	2.4 ± 1.1

	Bone marrow^*
		CD34⁺	CD34⁺	CD34⁺	CD34⁻		CD34⁺	CD34⁺	CD34⁻
Treatment (no. mice)	CD34⁺	CD19⁺	CD19⁻	CD7⁺	CD7⁺	CD34⁺	CD19⁻	CD7⁺	CD7⁺
No treatment (20)	19.0 ± 1.1	13.2 ± 1.2	4.9 ± 0.4	0.9 ± 0.1	0.8 ± 0.1	6.4 ± 0.9	2.7 ± 0.6	< 0.1	1.1 ± 0.2
IL-15/FL (7)	7.7 ± 1.8^*	2.1 ± 0.4^*	5.5 ± 1.8	1.3 ± 0.5	4.0 ± 1.1^*	7.3 ± 0.7	2.4 ± 0.4	< 0.1	5.3 ± 2.0^*
IL-15/FL/SCF (6)	9.7 ± 1.8†	2.7 ± 0.7^*	7.1 ± 1.4	1.1 ± 0.4	4.5 ± 1.3^*	5.5 ± 0.3	3.0 ± 0.5	< 0.1	4.5 ± 0.9^*
IL-15/FL/IL-12 (5)	8.3 ± 0.6†	4.2 ± 1.1^*	4.2 ± 0.5	0.7 ± 0.15	3.9 ± 1.3†	7.3 ± 2.4	1.5 ± 0.3	0.15 ± 0.02	2.4 ± 1.1

Values are mean percentages of human CD45⁺ cells ± SEMs.

P < .005.

†

P < .05.

View Large

This Feature Is Available To Subscribers Only