Table 1. Top 100 genes contributive for... | American Society of Hematology

Table 1.

Top 100 genes contributive for PCA1 component

Probe set	Name	Probe set	Name
B-cell genes		PC genes
U89922	Lymphotoxin β^*†	U95626	CCR2^*†
Z11697	CD83^*†‡	Z29574	BCMA^*†
M27394	CD20^*†‡	D84276	CD38^*†
X75042	REL^*†	L13720	GAS6^*†
X68149	CXCR5^*†‡	U25182	PRDX4/AOE372†
X01703	TUBA3	D49490	PDIR^*†
K01160	HLA-DQA1^*‡	U60519	CASP10^*†
HG4322	TUBB^*†‡	X76732	NUCB2†
D26070	ITPR1†	D82061	FABGL†
X67235	HHEX†	Z48199	SDC1^*
M91196	ICSBP1^*†‡	D14658	KIAA0102†
S76617	BLK^*†	U10362	GP36B^*†
D87465	KIAA0275	U25956	CD162/SELPLG^*†
M58459	RPS4Y†	X74837	MAN1A1^*†
U15085	HLA-DMB^*‡	D38583	S100A11
U83115	AIM1†	M83751	ARP^*†
L42324	GPR18†	U32944	PIN
X52425	IL4R^*†	M88458	KDELR2^*†
X62466	CD52^*‡	AJ000480	C8FW†
M20681	SLC2A3	U65785	ORP150†
D50683	TGFBR2†	M60092	AMPD1
M18255	PRKCB1	M75099	FKBP2†
X75918	NR4A2	L38961	ITM1^*†
X04602	IL6	M64098	HDLBP†
X82200	STAF50†	Z12962	RPL41
K02405	HLA-DQB1^*‡	U52682	IRF4^*†
U60975	SORL1	L42450	PDK1†
M16038	LYN‡	L36033	SDF1^*
M97287	SATB1†	D31762	KIAA0057†
X79536	HNRPA1	D31887	KIAA0062
X69111	ID3^*‡	M32334	ICAM2^*†
M54992	CD72	M63928	CD27^*†
U68019	MADH3	M94250	MDK
U26710	CBLB	M23294	HEXB†
M24069	CSDA	L06419	PLOD†
U51240	LAPTM5	U89606	PDXK†
HG3576	HLA-DRB1^*‡	M38690	CD9^*
Z35278	RUNX3^*	L02648	TCN2
X99050	UVRAG	D49824	HLAB
D50930	KIAA0140	X55885	KDELR1^*†
M28827	CD1c^*	D32050	AARS†
Y08765	ZNF162	M57710	LGALS3†
X59350	CD22^*‡	L36531	ITGA8
S66431	RBBP2	M31627	XBP1^*‡
		L34657	CD31/PECAM1^*
		Y00282	RBN2†
		L40391	TMP21†
		X15187	TRA1†
		M32304	TIMP2
		U90546	BTN3A2
		X69910	P63^*†
		U65093	CITED2†
		M12529	APOE
		X57398	PM5†
		M14219	DCN†
		L13977	PRCP

Probe set	Name	Probe set	Name
B-cell genes		PC genes
U89922	Lymphotoxin β^*†	U95626	CCR2^*†
Z11697	CD83^*†‡	Z29574	BCMA^*†
M27394	CD20^*†‡	D84276	CD38^*†
X75042	REL^*†	L13720	GAS6^*†
X68149	CXCR5^*†‡	U25182	PRDX4/AOE372†
X01703	TUBA3	D49490	PDIR^*†
K01160	HLA-DQA1^*‡	U60519	CASP10^*†
HG4322	TUBB^*†‡	X76732	NUCB2†
D26070	ITPR1†	D82061	FABGL†
X67235	HHEX†	Z48199	SDC1^*
M91196	ICSBP1^*†‡	D14658	KIAA0102†
S76617	BLK^*†	U10362	GP36B^*†
D87465	KIAA0275	U25956	CD162/SELPLG^*†
M58459	RPS4Y†	X74837	MAN1A1^*†
U15085	HLA-DMB^*‡	D38583	S100A11
U83115	AIM1†	M83751	ARP^*†
L42324	GPR18†	U32944	PIN
X52425	IL4R^*†	M88458	KDELR2^*†
X62466	CD52^*‡	AJ000480	C8FW†
M20681	SLC2A3	U65785	ORP150†
D50683	TGFBR2†	M60092	AMPD1
M18255	PRKCB1	M75099	FKBP2†
X75918	NR4A2	L38961	ITM1^*†
X04602	IL6	M64098	HDLBP†
X82200	STAF50†	Z12962	RPL41
K02405	HLA-DQB1^*‡	U52682	IRF4^*†
U60975	SORL1	L42450	PDK1†
M16038	LYN‡	L36033	SDF1^*
M97287	SATB1†	D31762	KIAA0057†
X79536	HNRPA1	D31887	KIAA0062
X69111	ID3^*‡	M32334	ICAM2^*†
M54992	CD72	M63928	CD27^*†
U68019	MADH3	M94250	MDK
U26710	CBLB	M23294	HEXB†
M24069	CSDA	L06419	PLOD†
U51240	LAPTM5	U89606	PDXK†
HG3576	HLA-DRB1^*‡	M38690	CD9^*
Z35278	RUNX3^*	L02648	TCN2
X99050	UVRAG	D49824	HLAB
D50930	KIAA0140	X55885	KDELR1^*†
M28827	CD1c^*	D32050	AARS†
Y08765	ZNF162	M57710	LGALS3†
X59350	CD22^*‡	L36531	ITGA8
S66431	RBBP2	M31627	XBP1^*‡
		L34657	CD31/PECAM1^*
		Y00282	RBN2†
		L40391	TMP21†
		X15187	TRA1†
		M32304	TIMP2
		U90546	BTN3A2
		X69910	P63^*†
		U65093	CITED2†
		M12529	APOE
		X57398	PM5†
		M14219	DCN†
		L13977	PRCP

The 44 genes with the highest positive PCA1 coefficients (B-cell genes) and the 56 genes with the highest negative PCA1 coefficients (PC genes) are listed. Genes coding for immunoglobulins have been omitted

Genes described previously as down-regulated or up-regulated during B-cell maturation

†

Genes statistically differentially expressed between the 2 B-cell subsets and the 3 PC subsets (available as supplementary data in Table S3)

‡

Genes recently shown to be extinguished or induced by ectopic Blimp-1 expression

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