Ferric chloride thrombosis model
Founder line . | Time to initial occlusion, mins ± 1 SD . | Initial occlusion (%) . | Occluded at 30 min (%) . |
|---|---|---|---|
| WT | 8.8±4.3 | 31/34 (91) | 29/34 (85) |
| No. 13 | 6.8±3.3 | 9/10 (90) | 9/10 (90) |
| No. 19 | 10.3±4.8 | 4/20 (20)* | 1/20 (5)* |
| WT + TA | 8.3±1.1 | 5/5 (100) | 4/5 (80) |
| No. 19 + TA | 9.4±1.6 | 5/5 (100) | 5/5 (100) |
Founder line . | Time to initial occlusion, mins ± 1 SD . | Initial occlusion (%) . | Occluded at 30 min (%) . |
|---|---|---|---|
| WT | 8.8±4.3 | 31/34 (91) | 29/34 (85) |
| No. 13 | 6.8±3.3 | 9/10 (90) | 9/10 (90) |
| No. 19 | 10.3±4.8 | 4/20 (20)* | 1/20 (5)* |
| WT + TA | 8.3±1.1 | 5/5 (100) | 4/5 (80) |
| No. 19 + TA | 9.4±1.6 | 5/5 (100) | 5/5 (100) |
Initial occlusion refers to the time to first occlusion in those animals that developed any occlusive thrombi
WT indicates wild-type littermates combined for line nos. 13 and 19; TA, drinking water contained tranexamic acid (20 mg/mL)
P < .0001 compared with wild type