Platelet transfusion ferric chloride thrombosis model
Founder line . | . | . | . | . | |
|---|---|---|---|---|---|
| Recipient . | Donor . | Time to initial occlusion, min . | Initial occlusion (%) . | Occluded at 30 min (%) . | |
| WT | Buffer | 9.3±1.2 | 5/5 (100) | 5/5 (100) | |
| WT | WT | 8.2±1.4 | 5/5 (100) | 5/5 (100) | |
| WT | No. 19 | 12.5 | 1/10 (10)* | 0/10 (0)* | |
| WT + TA | No. 19 | 8.3±1.9 | 5/5 (100) | 4/5 (80) | |
| WT | No. 19 + TA | 10.5; 22.5 | 2/3 (67) | 0/3 (0) | |
| No. 19 | WT | — | 0/3 (0) | 0/3 (0) | |
Founder line . | . | . | . | . | |
|---|---|---|---|---|---|
| Recipient . | Donor . | Time to initial occlusion, min . | Initial occlusion (%) . | Occluded at 30 min (%) . | |
| WT | Buffer | 9.3±1.2 | 5/5 (100) | 5/5 (100) | |
| WT | WT | 8.2±1.4 | 5/5 (100) | 5/5 (100) | |
| WT | No. 19 | 12.5 | 1/10 (10)* | 0/10 (0)* | |
| WT + TA | No. 19 | 8.3±1.9 | 5/5 (100) | 4/5 (80) | |
| WT | No. 19 + TA | 10.5; 22.5 | 2/3 (67) | 0/3 (0) | |
| No. 19 | WT | — | 0/3 (0) | 0/3 (0) | |
Time to initial occlusion, WT, and TA are defined in Table 1; buffer indicates gel-filtering buffer. — indicates that no animal occluded at any time
P < .0001 compared with wild type receiving wild-type platelets