Patient characteristics, transplantation modalities, and acute GvHD, N = 132
Observation time | Median, 23 mo (range, 2-71 mo) |
| Age at SCT | Median, 8 y (range, 0.1-20 y) |
| Diagnosis | Acute leukemia, n = 63 |
| Chronic leukemia/myelodysplasia/solid tumor, n = 23 | |
| Severe combined immunodeficiency, n = 8 | |
| Inborn errors/severe aplastic anemia, n = 38 | |
| Conditioning | Chemoconditioning, n = 80 |
| Irradiation (TBI/TLI)-containing conditioning, n = 52 | |
| Additional antithymocyte globulin (ATG), n = 103 | |
| Donor | HLA-matched sibling donor, n = 35 |
| HLA-matched unrelated donor, n = 68 | |
| HLA-mismatched family donor, n = 29 | |
| Graft | Bone marrow without CD34+ positive selection, n = 62 |
| Peripheral blood stem cells without CD34+ positive selection, n = 12 | |
| Peripheral blood stem cells with CD34+ positive selection, n = 58 | |
| Acute GvHD | All patients (pts) (n = 132) |
| GvHD, any grade, n = 72 | |
| GvHD, grade III-IV, n = 27 | |
| AdV-negative pts (n = 96) | |
| GvHD, any grade, n = 51 | |
| GvHD, grade III-IV, n = 18 | |
| AdV-positive pts at any site, n = 36 | |
| GvHD, any grade, n = 21 | |
| GvHD, grade III-IV, n = 9 | |
| AdV-positive pts in PB, n = 11 | |
| GvHD, any grade, n = 5 | |
| GvHD, grade III-IV, n = 3 |
Observation time | Median, 23 mo (range, 2-71 mo) |
| Age at SCT | Median, 8 y (range, 0.1-20 y) |
| Diagnosis | Acute leukemia, n = 63 |
| Chronic leukemia/myelodysplasia/solid tumor, n = 23 | |
| Severe combined immunodeficiency, n = 8 | |
| Inborn errors/severe aplastic anemia, n = 38 | |
| Conditioning | Chemoconditioning, n = 80 |
| Irradiation (TBI/TLI)-containing conditioning, n = 52 | |
| Additional antithymocyte globulin (ATG), n = 103 | |
| Donor | HLA-matched sibling donor, n = 35 |
| HLA-matched unrelated donor, n = 68 | |
| HLA-mismatched family donor, n = 29 | |
| Graft | Bone marrow without CD34+ positive selection, n = 62 |
| Peripheral blood stem cells without CD34+ positive selection, n = 12 | |
| Peripheral blood stem cells with CD34+ positive selection, n = 58 | |
| Acute GvHD | All patients (pts) (n = 132) |
| GvHD, any grade, n = 72 | |
| GvHD, grade III-IV, n = 27 | |
| AdV-negative pts (n = 96) | |
| GvHD, any grade, n = 51 | |
| GvHD, grade III-IV, n = 18 | |
| AdV-positive pts at any site, n = 36 | |
| GvHD, any grade, n = 21 | |
| GvHD, grade III-IV, n = 9 | |
| AdV-positive pts in PB, n = 11 | |
| GvHD, any grade, n = 5 | |
| GvHD, grade III-IV, n = 3 |