Demographics of ITP patients during thrombocytopenic phase
. | . | . | . | . | . | . | Autoantibody . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | Anti-GPIIb/IIIa . | . | Anti-GPIb . | . | |||
| Patient no. . | Sex . | Age . | Diagnosis . | Plt count, × 103/μL . | Treatment* . | Yield of CD41+PI+, % of control† . | IgG . | IgM . | IgG . | IgM . | |||
| Group O | |||||||||||||
| 1 | M | 4 y | Acute | 16 | No meds | 115.00 | - | - | - | - | |||
| 2 | M | 8 y | Acute | 15 | After IVIG | 94.00 | - | - | - | - | |||
| 3 | M | 11 mo | Acute | 5 | After IVIG test | 90.00 | - | - | - | - | |||
| 4 | M | 7 y | Acute | 19 | No meds | 69.00 | - | - | - | - | |||
| 5 | F | 1 y | Acute | 5 | No meds | 52.98 | - | - | - | - | |||
| 6 | F | 14 y | Acute | 5 | No meds | 116.07 | - | - | - | - | |||
| 7 | M | 8 y | Acute | 10 | No meds | 82.00 | - | - | - | - | |||
| 8 | F | 9 y | Acute | 28 | No meds | 60.00 | - | - | - | - | |||
| 9 | F | 9 y | Acute | 10 | No meds | 111.00 | - | - | - | - | |||
| 10 | F | 3 y | Acute | 54 | No meds | 130.00 | - | - | - | - | |||
| 11 | M | 3 y | Acute | 14 | No meds | 94.00 | - | - | - | - | |||
| 12 | F | 15 y | Acute | 11 | No meds | 64.00 | - | - | - | - | |||
| 13 | F | 1 y | Acute | 6 | No meds | 125.00 | - | - | - | - | |||
| 14 | F | 8 mo | Acute | 15 | No meds | 83.51 | - | - | - | - | |||
| 15 | F | 15 y | Acute | 20 | No meds | 86.00 | - | - | - | - | |||
| Group IIb/IIIa/Ib | |||||||||||||
| 16 | M | 3 m | Acute | 17 | 2 d after IVIG | 47.67 | + | - | + | + | |||
| 17 | F | 4 y | Acute | 8 | No meds | 55.00 | + | - | + | + | |||
| 18 | F | 7 y | Acute | 18 | No meds | 83.00 | - | + | + | + | |||
| 19 | M | 6 y | Acute | 7 | No meds | 30.00 | - | + | + | + | |||
| 20 | F | 3 y | Acute | 14 | No meds | 69.53 | + | + | - | + | |||
| 21 | M | 4 y | Acute | 3 | No meds | 19.87 | + | + | + | + | |||
| 22 | M | 3 y | Acute | 16 | No meds | 59.60 | + | - | + | - | |||
| 23 | F | 3 y | Acute | 4 | No meds | 79.00 | + | - | - | + | |||
| 24 | M | 11 y | Acute | 37 | No meds | 36.00 | + | - | + | - | |||
| 25 | M | 1 y | Acute | 37 | After IVIG | 33.84 | + | - | + | + | |||
| 26 | F | 1 y | Acute | 2 | No meds | 43.00 | - | - | - | + | |||
| 27 | F | 11 m | Acute | 7 | No meds | 37.09 | + | - | + | + | |||
| 28 | M | 2 y | Acute | 7 | No meds | 82.00 | + | - | + | + | |||
| 29 | M | 4 y | Acute | 15 | After IVIG | 15.00 | + | - | + | + | |||
| 30 | F | 5 y | Acute | 17 | 2 d after IVIG | 77.00 | - | + | - | + | |||
| 31 | M | 12 y | Chronic | 34 | No meds | 70.20 | + | - | + | - | |||
| 32 | M | 6 y | Chronic | 18 | Prednisone | 65.56 | + | - | + | + | |||
| 33 | M | 9 y | Chronic | 8 | No meds | 55.36 | - | + | - | + | |||
| 34 | F | 13 y | Acute | 21 | No meds | 24.00 | + | - | - | + | |||
| Group IIb/IIIa | |||||||||||||
| 35 | M | 6 y | Acute | 10 | No meds | 122.00 | + | - | - | - | |||
| 36 | M | 1 y | Acute | 6 | No meds | 114.00 | - | + | - | - | |||
| 37 | F | 4 y | Chronic | 57 | No meds | 84.00 | + | - | - | - | |||
| 38 | M | 3 y | Chronic | 36 | Prednisone | 47.88 | - | + | - | - | |||
| 39 | F | 14 y | Acute | 4 | No meds | 28.00 | + | - | - | - | |||
| Group Ib | |||||||||||||
| 40 | F | 7 y | Acute | 17 | No meds | 78.00 | - | - | + | - | |||
| 41 | M | 2 y | Acute | 18 | No meds | 48.75 | - | - | - | + | |||
| 42 | F | 1 y | Acute | 8 | No meds | 46.24 | - | - | - | + | |||
| 43 | M | 5 y | Acute | 9 | No meds | 49.00 | - | - | - | + | |||
| 44 | M | 3 y | Acute | 9 | No meds | 75.00 | - | - | + | + | |||
| 45 | M | 3 y | Acute | 7 | No meds | 69.00 | - | - | - | + | |||
| 46 | M | 4 y | Acute | 6 | No meds | 109.00 | - | - | - | + | |||
| 47 | M | 4 y | Acute | 3 | No meds | 69.00 | - | - | - | + | |||
| 48 | M | 2 y | Acute | 12 | No meds | 52.00 | - | - | - | + | |||
| 49 | M | 3 y | Acute | 13 | No meds | 45.00 | - | - | - | + | |||
| 50 | F | 16 y | Chronic | 49 | No meds | 30.13 | - | - | - | + | |||
| 51 | F | 16 y | Chronic | <10 | No meds | 6.00 | - | - | - | + | |||
| 52 | M | 4 y | Chronic | 7 | No meds | 53.00 | - | - | - | + | |||
| 53 | F | 8 y | Chronic | 9 | Prednisone | 16.00 | - | - | + | + | |||
. | . | . | . | . | . | . | Autoantibody . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | Anti-GPIIb/IIIa . | . | Anti-GPIb . | . | |||
| Patient no. . | Sex . | Age . | Diagnosis . | Plt count, × 103/μL . | Treatment* . | Yield of CD41+PI+, % of control† . | IgG . | IgM . | IgG . | IgM . | |||
| Group O | |||||||||||||
| 1 | M | 4 y | Acute | 16 | No meds | 115.00 | - | - | - | - | |||
| 2 | M | 8 y | Acute | 15 | After IVIG | 94.00 | - | - | - | - | |||
| 3 | M | 11 mo | Acute | 5 | After IVIG test | 90.00 | - | - | - | - | |||
| 4 | M | 7 y | Acute | 19 | No meds | 69.00 | - | - | - | - | |||
| 5 | F | 1 y | Acute | 5 | No meds | 52.98 | - | - | - | - | |||
| 6 | F | 14 y | Acute | 5 | No meds | 116.07 | - | - | - | - | |||
| 7 | M | 8 y | Acute | 10 | No meds | 82.00 | - | - | - | - | |||
| 8 | F | 9 y | Acute | 28 | No meds | 60.00 | - | - | - | - | |||
| 9 | F | 9 y | Acute | 10 | No meds | 111.00 | - | - | - | - | |||
| 10 | F | 3 y | Acute | 54 | No meds | 130.00 | - | - | - | - | |||
| 11 | M | 3 y | Acute | 14 | No meds | 94.00 | - | - | - | - | |||
| 12 | F | 15 y | Acute | 11 | No meds | 64.00 | - | - | - | - | |||
| 13 | F | 1 y | Acute | 6 | No meds | 125.00 | - | - | - | - | |||
| 14 | F | 8 mo | Acute | 15 | No meds | 83.51 | - | - | - | - | |||
| 15 | F | 15 y | Acute | 20 | No meds | 86.00 | - | - | - | - | |||
| Group IIb/IIIa/Ib | |||||||||||||
| 16 | M | 3 m | Acute | 17 | 2 d after IVIG | 47.67 | + | - | + | + | |||
| 17 | F | 4 y | Acute | 8 | No meds | 55.00 | + | - | + | + | |||
| 18 | F | 7 y | Acute | 18 | No meds | 83.00 | - | + | + | + | |||
| 19 | M | 6 y | Acute | 7 | No meds | 30.00 | - | + | + | + | |||
| 20 | F | 3 y | Acute | 14 | No meds | 69.53 | + | + | - | + | |||
| 21 | M | 4 y | Acute | 3 | No meds | 19.87 | + | + | + | + | |||
| 22 | M | 3 y | Acute | 16 | No meds | 59.60 | + | - | + | - | |||
| 23 | F | 3 y | Acute | 4 | No meds | 79.00 | + | - | - | + | |||
| 24 | M | 11 y | Acute | 37 | No meds | 36.00 | + | - | + | - | |||
| 25 | M | 1 y | Acute | 37 | After IVIG | 33.84 | + | - | + | + | |||
| 26 | F | 1 y | Acute | 2 | No meds | 43.00 | - | - | - | + | |||
| 27 | F | 11 m | Acute | 7 | No meds | 37.09 | + | - | + | + | |||
| 28 | M | 2 y | Acute | 7 | No meds | 82.00 | + | - | + | + | |||
| 29 | M | 4 y | Acute | 15 | After IVIG | 15.00 | + | - | + | + | |||
| 30 | F | 5 y | Acute | 17 | 2 d after IVIG | 77.00 | - | + | - | + | |||
| 31 | M | 12 y | Chronic | 34 | No meds | 70.20 | + | - | + | - | |||
| 32 | M | 6 y | Chronic | 18 | Prednisone | 65.56 | + | - | + | + | |||
| 33 | M | 9 y | Chronic | 8 | No meds | 55.36 | - | + | - | + | |||
| 34 | F | 13 y | Acute | 21 | No meds | 24.00 | + | - | - | + | |||
| Group IIb/IIIa | |||||||||||||
| 35 | M | 6 y | Acute | 10 | No meds | 122.00 | + | - | - | - | |||
| 36 | M | 1 y | Acute | 6 | No meds | 114.00 | - | + | - | - | |||
| 37 | F | 4 y | Chronic | 57 | No meds | 84.00 | + | - | - | - | |||
| 38 | M | 3 y | Chronic | 36 | Prednisone | 47.88 | - | + | - | - | |||
| 39 | F | 14 y | Acute | 4 | No meds | 28.00 | + | - | - | - | |||
| Group Ib | |||||||||||||
| 40 | F | 7 y | Acute | 17 | No meds | 78.00 | - | - | + | - | |||
| 41 | M | 2 y | Acute | 18 | No meds | 48.75 | - | - | - | + | |||
| 42 | F | 1 y | Acute | 8 | No meds | 46.24 | - | - | - | + | |||
| 43 | M | 5 y | Acute | 9 | No meds | 49.00 | - | - | - | + | |||
| 44 | M | 3 y | Acute | 9 | No meds | 75.00 | - | - | + | + | |||
| 45 | M | 3 y | Acute | 7 | No meds | 69.00 | - | - | - | + | |||
| 46 | M | 4 y | Acute | 6 | No meds | 109.00 | - | - | - | + | |||
| 47 | M | 4 y | Acute | 3 | No meds | 69.00 | - | - | - | + | |||
| 48 | M | 2 y | Acute | 12 | No meds | 52.00 | - | - | - | + | |||
| 49 | M | 3 y | Acute | 13 | No meds | 45.00 | - | - | - | + | |||
| 50 | F | 16 y | Chronic | 49 | No meds | 30.13 | - | - | - | + | |||
| 51 | F | 16 y | Chronic | <10 | No meds | 6.00 | - | - | - | + | |||
| 52 | M | 4 y | Chronic | 7 | No meds | 53.00 | - | - | - | + | |||
| 53 | F | 8 y | Chronic | 9 | Prednisone | 16.00 | - | - | + | + | |||
No meds indicates plasma samples were collected at diagnosis before the medication was given; After IVIG test, after IVIG; 2 d after IVIG, plasma samples were collected immediately after a test dose of IVIG, a full dose of IVIG, or 2 days after a full dose of IVIG; prednisone, that patient was taking prednisone regularly when plasma samples were collected
The average yield of CD41+PI+ of 4 group IIb/IIIa/Ib samples that received IVIG was 43.5 ± 26.1