Genes modulated in lungs of SAD mice exposed to hypoxia/reoxygenation and effects of inhaled nitric oxide (NO)
. | . | . | Hypoxia . | . | . | Hypoxia plus NO . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GenBank accession no. . | Symbol . | Description . | 4 h . | 10 h . | 46 h . | 4 h . | 10 h . | 46 h . | ||||
| M36829 | Hspcb | Heat shock protein 1, beta | 0.3 | 3.5 | 1.0 | 1.0 | 1.0 | 1.0 | ||||
| M13806 | Krt1-14 | Keratin complex 1, acidic, gene 14 | 0.4 | 0.4 | 0.4 | 1.0 | 1.0 | 1.0 | ||||
| J05186 | Cai | Calcium binding protein, intestinal | 0.4 | 0.4 | 0.4 | 1.0 | 0.1 | 0.4 | ||||
| L12705 | En2 | Engrailed 2 | 0.4 | 0.1 | 0.4 | 0.3 | 1.0 | 1.0 | ||||
| Z22703 | Fgf7 | Fibroblast growth factor 7 | 2.0 | 0.2 | 0.4 | 1.0 | 0.1 | 0.5 | ||||
| U10440 | Cdkn1b | Cyclin-dependent kinase inhibitor 1B (P27) | 1.0 | 0.5 | 2.6 | 1.0 | 1.0 | 1.0 | ||||
| D12482 | Fgf8 | Fibroblast growth factor 8 | 1.0 | 1.0 | 2.3 | 0.2 | 5.6 | 2.2 | ||||
| U06119 | Ctsh | Cathepsin H | 1.0 | 11.0 | 6.0 | 1.0 | 1.0 | 6.6 | ||||
| M36830 | Hsp86-1 | Heat shock protein, 1 | 1.0 | 3.8 | 1.0 | 1.0 | 1.0 | 1.5 | ||||
| U20532 | Nfe212 | Nuclear factor erythroid derived 2 like 2 | 1.0 | 2.3 | 1.0 | 1.0 | 0.9 | 1.0 | ||||
| M95200 | Vegfa | Vascular endothelial growth factor A | 1.0 | 1.0 | 2.7 | 1.0 | 1.0 | 10.0 | ||||
| J04696 | Gstm2 | Glutathione S-transferase, mu 2 | 1.0 | 2.0 | 2.1 | 2.3 | 1.0 | 1.0 | ||||
| L19622 | Timp3 | Tissue inhibitor of metalloproteinase 3 | 1.0 | 1.0 | 3.5 | 1.0 | 1.0 | 3.5 | ||||
| U43512 | Dag1 | Dystroglycan 1 | 2.0 | 2.1 | 2.1 | 1.0 | 0.5 | 3.2 | ||||
| D26046 | Atbf1 | AT motif binding factor 1 | 2.0 | 0.2 | 0.2 | 1.0 | 2.0 | 0.3 | ||||
| J04946 | Ace | Angiotensin converting enzyme | 3.0 | 3.0 | 2.3 | 1.0 | 4.0 | 2.34 | ||||
| M84819 | Rxrg | Retinoid X receptor gamma | 5.7 | 0.1 | 1.0 | 7.7 | 0.2 | 0.2 | ||||
| X62622 | Timp2 | Tissue inhibitor of metalloproteinase 2 | 1.0 | 1.0 | 2.2 | 1.0 | 1.0 | 2.2 | ||||
| M29697 | Il7r | Interleukin 7 receptor | 1.0 | 1.0 | 1.0 | 1.0 | 0.1 | 1.0 | ||||
| J03752 | Mgst1 | Microsomal glutathione S-transferase 1 | 1.0 | 4.0 | 1.0 | 1.0 | 4.2 | 1.0 | ||||
| X92411 | Rad23b | RAD23b homolog (S. cerevisiae) | 1.0 | 1.0 | 1.0 | 1.0 | 2.88 | 1.0 | ||||
| P19001 | none | Type I cytoskeletal keratin 19 | 1.0 | 3.5 | 3.5 | 1.0 | 2.5 | 2.5 | ||||
| M94335 | Akt1 | Thymoma viral proto-oncogene 1 | 1.0 | 1.0 | 1.0 | 1.0 | 3.32 | 1.0 | ||||
. | . | . | Hypoxia . | . | . | Hypoxia plus NO . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GenBank accession no. . | Symbol . | Description . | 4 h . | 10 h . | 46 h . | 4 h . | 10 h . | 46 h . | ||||
| M36829 | Hspcb | Heat shock protein 1, beta | 0.3 | 3.5 | 1.0 | 1.0 | 1.0 | 1.0 | ||||
| M13806 | Krt1-14 | Keratin complex 1, acidic, gene 14 | 0.4 | 0.4 | 0.4 | 1.0 | 1.0 | 1.0 | ||||
| J05186 | Cai | Calcium binding protein, intestinal | 0.4 | 0.4 | 0.4 | 1.0 | 0.1 | 0.4 | ||||
| L12705 | En2 | Engrailed 2 | 0.4 | 0.1 | 0.4 | 0.3 | 1.0 | 1.0 | ||||
| Z22703 | Fgf7 | Fibroblast growth factor 7 | 2.0 | 0.2 | 0.4 | 1.0 | 0.1 | 0.5 | ||||
| U10440 | Cdkn1b | Cyclin-dependent kinase inhibitor 1B (P27) | 1.0 | 0.5 | 2.6 | 1.0 | 1.0 | 1.0 | ||||
| D12482 | Fgf8 | Fibroblast growth factor 8 | 1.0 | 1.0 | 2.3 | 0.2 | 5.6 | 2.2 | ||||
| U06119 | Ctsh | Cathepsin H | 1.0 | 11.0 | 6.0 | 1.0 | 1.0 | 6.6 | ||||
| M36830 | Hsp86-1 | Heat shock protein, 1 | 1.0 | 3.8 | 1.0 | 1.0 | 1.0 | 1.5 | ||||
| U20532 | Nfe212 | Nuclear factor erythroid derived 2 like 2 | 1.0 | 2.3 | 1.0 | 1.0 | 0.9 | 1.0 | ||||
| M95200 | Vegfa | Vascular endothelial growth factor A | 1.0 | 1.0 | 2.7 | 1.0 | 1.0 | 10.0 | ||||
| J04696 | Gstm2 | Glutathione S-transferase, mu 2 | 1.0 | 2.0 | 2.1 | 2.3 | 1.0 | 1.0 | ||||
| L19622 | Timp3 | Tissue inhibitor of metalloproteinase 3 | 1.0 | 1.0 | 3.5 | 1.0 | 1.0 | 3.5 | ||||
| U43512 | Dag1 | Dystroglycan 1 | 2.0 | 2.1 | 2.1 | 1.0 | 0.5 | 3.2 | ||||
| D26046 | Atbf1 | AT motif binding factor 1 | 2.0 | 0.2 | 0.2 | 1.0 | 2.0 | 0.3 | ||||
| J04946 | Ace | Angiotensin converting enzyme | 3.0 | 3.0 | 2.3 | 1.0 | 4.0 | 2.34 | ||||
| M84819 | Rxrg | Retinoid X receptor gamma | 5.7 | 0.1 | 1.0 | 7.7 | 0.2 | 0.2 | ||||
| X62622 | Timp2 | Tissue inhibitor of metalloproteinase 2 | 1.0 | 1.0 | 2.2 | 1.0 | 1.0 | 2.2 | ||||
| M29697 | Il7r | Interleukin 7 receptor | 1.0 | 1.0 | 1.0 | 1.0 | 0.1 | 1.0 | ||||
| J03752 | Mgst1 | Microsomal glutathione S-transferase 1 | 1.0 | 4.0 | 1.0 | 1.0 | 4.2 | 1.0 | ||||
| X92411 | Rad23b | RAD23b homolog (S. cerevisiae) | 1.0 | 1.0 | 1.0 | 1.0 | 2.88 | 1.0 | ||||
| P19001 | none | Type I cytoskeletal keratin 19 | 1.0 | 3.5 | 3.5 | 1.0 | 2.5 | 2.5 | ||||
| M94335 | Akt1 | Thymoma viral proto-oncogene 1 | 1.0 | 1.0 | 1.0 | 1.0 | 3.32 | 1.0 | ||||
The values are presented as the gene expression ratio between any given time point and normoxic SAD mice