Chromosomal abnormalities in dominant-negative hTERT-transduced CD4+ T cells
DNA construct used for CD4+ T-cell transduction . | No. of metaphases analyzed . | No. of metaphases with dicentric chromosomes . |
|---|---|---|
| GFP | 28 | 0 |
| DN-hTERT-GFP | 16 | 3* |
| hTERT-GFP | 20 | 0 |
DNA construct used for CD4+ T-cell transduction . | No. of metaphases analyzed . | No. of metaphases with dicentric chromosomes . |
|---|---|---|
| GFP | 28 | 0 |
| DN-hTERT-GFP | 16 | 3* |
| hTERT-GFP | 20 | 0 |
Chromosome end-to-end fusions found: (1q;20q) (7p;22p) (6q;10p)