Table 3. Univariate analysis of... | American Society of Hematology

Table 3.

Univariate analysis of potential prognostic factors

Parameter	No. patients	5-y survival probability rate, %	P
Sex			.49
Male	61	39.2
Female	60	52.2
Age, y			.11
Younger than 60	20	65.4
60-70	48	46.9
Older than 70	53	37.0
Stage			< .0001
I	4	100
II	31	72.0
IIIA	67	40.6
IIIB	19	9.2
MM subtype			.21
IgG	62	42.5
IgA	34	38.4
BJ	19	57.9
NS	5	100
Treatment			.02
Chemotherapy alone	82	39.8
HDT + ASCT	38	60.5
Bone disease			.0002
A	10	88.9
B	28	67.7
C	83	31.7
sRANKL, pM			< .0001
0-8	75	65.7
Greater than 8	46	10.9
OPG, pM			.001
Less than 3	30	6.9
3-6	58	26.9
Greater than 6	33	78.8
sRANKL/OPG ratio			< .0001
Less than 1	35	89.1
1-3	54	32.1
Greater than 3	32	0
TRACP-5b, U/L			< .0001
Less than 5	31	91.7
5-10	66	30.5
Greater than 10	24	8.2
NTX, nm BCE/nM creatinine			< .0001
Less than 80	27	87.9
80-150	46	46.0
Greater than 150	48	20.8
OC, ng/mL			.072
Less than 10	41	34.0
10-20	29	55.2
Greater than 20	51	51.4
bALP, U/L			.678
Less than 20	30	34.7
20-50	54	53.4
Greater than 50	37	39.3
β₂-microglobulin, mg/L			< .0001
0-3	57	77.9
Greater than 3	64	16.2
CRP, mg/L			< .0001
0-10	89	60.0
Greater than 10	32	10.0
IL-6, pg/mL			< .0001
Less than 12	32	79.8
12-30	37	46.0
31-50	25	29.9
Greater than 50	27	0
Paraprotein (IgG, IgA, IgD MM)			0.18
0-30 g/L	55	51.0
Greater than 30 g/L	42	32.4

Parameter	No. patients	5-y survival probability rate, %	P
Sex			.49
Male	61	39.2
Female	60	52.2
Age, y			.11
Younger than 60	20	65.4
60-70	48	46.9
Older than 70	53	37.0
Stage			< .0001
I	4	100
II	31	72.0
IIIA	67	40.6
IIIB	19	9.2
MM subtype			.21
IgG	62	42.5
IgA	34	38.4
BJ	19	57.9
NS	5	100
Treatment			.02
Chemotherapy alone	82	39.8
HDT + ASCT	38	60.5
Bone disease			.0002
A	10	88.9
B	28	67.7
C	83	31.7
sRANKL, pM			< .0001
0-8	75	65.7
Greater than 8	46	10.9
OPG, pM			.001
Less than 3	30	6.9
3-6	58	26.9
Greater than 6	33	78.8
sRANKL/OPG ratio			< .0001
Less than 1	35	89.1
1-3	54	32.1
Greater than 3	32	0
TRACP-5b, U/L			< .0001
Less than 5	31	91.7
5-10	66	30.5
Greater than 10	24	8.2
NTX, nm BCE/nM creatinine			< .0001
Less than 80	27	87.9
80-150	46	46.0
Greater than 150	48	20.8
OC, ng/mL			.072
Less than 10	41	34.0
10-20	29	55.2
Greater than 20	51	51.4
bALP, U/L			.678
Less than 20	30	34.7
20-50	54	53.4
Greater than 50	37	39.3
β₂-microglobulin, mg/L			< .0001
0-3	57	77.9
Greater than 3	64	16.2
CRP, mg/L			< .0001
0-10	89	60.0
Greater than 10	32	10.0
IL-6, pg/mL			< .0001
Less than 12	32	79.8
12-30	37	46.0
31-50	25	29.9
Greater than 50	27	0
Paraprotein (IgG, IgA, IgD MM)			0.18
0-30 g/L	55	51.0
Greater than 30 g/L	42	32.4

HDT indicates high-dose therapy; ASCT, autologous stem cell transplantation